Nefopam

DB12293ApprovedInvestigationalWithdrawnSmall molecule

Nefopam is a non-opioid analgesic used for moderate to severe pain, especially post-surgical pain. Nefopam is under investigation for the prevention of Cholecystitis and Post Anaesthetic Shivering.

Chemical structure of Nefopam
Mechanism
Curator reviewed
Formula / weight
C17H19NO · 253.345 g/mol (avg)

Resolves to

Compound
UNII4UP8060B7JCAS13669-70-0ChEMBLCHEMBL465026ChEBI88318PubChem4450
Clinical / RWD
RxNorm7285ATCN02BG06
Structure
InChIKeyRGPDEAGGEXEMMM-UHFFFAOYSA-NSMILESCN1CCOC(C2=CC=CC=C2)C2=CC=CC=C2C1
Targets
P23975SLC6A2Q01959SLC6A3P31645SLC6A4Q8NER1TRPV1P25021HRH2P35367HRH1

What you can answer from here — as of August 30, 2026

7Protein targetsEach mapped to UniProt, with action and pharmacological action
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1Drug interactionStructured to mechanism, not free text
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53Clinical trialsPhase, status and sponsor resolved per trial
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1Structured indicationCondition, population, route and combination as fields, not prose
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5ContraindicationsEach with its own population and attribute set
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7Marketed productsAcross 4 countries and 6 labellers
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1ATC codeIncluding every combination product, plus 8 drug categories
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14+ReferencesStructured and connected to the statements they support
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Which drugs share a target with Nefopam, and which of those have an active Phase 3 trial?

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