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Displaying results 7681 - 7690 of 10000 in total
  1. Drug

    LNP-nCoVsaRNA Vaccine

    go.drugbank.com/drugs/DB15799
    Experimental

    LNP-nCoVsaRNA is a purified, synthetic mRNA vaccine candidate encoding the S glycoprotein of SARS-CoV-2, which is used primarily by the virus to attach to and invade human cells. … As of July 2020, a clinical trial (COVAC1) is underway (ISRCTN17072692) to test the safety and immunogenicity of the vaccine.

  2. Drug

    Desmoteplase

    go.drugbank.com/drugs/DB04925
    Investigational

    Desmoteplase is a recombinant form of vampire bat DSPA (Salivary plasminogen activator alpha 1). … Desmoteplase is a chemical in the saliva of vampire bats. It activates plasminogen to the serine protease, plasmin. Plasmin acts by breaking down fibrin blood clots.

    Synonyms: rDSPA alpha 1, Salivary plasminogen activator alpha 1, Desmodus rotundus
  3. Drug

    Epicept NP-1

    go.drugbank.com/drugs/DB05492
    Investigational

    EpiCept NP-1 Cream is a patented formulation containing two FDA-approved drugs, amitriptyline (a widely-used antidepressant) and ketamine (an NMDA antagonist that is used as an anesthetic). … EpiCept NP-1 is a prescription topical analgesic cream designed to provide effective, long-term relief from the pain of peripheral neuropathies.

    Synonyms: Epicept NP-1
  4. Drug

    Tioconazole

    go.drugbank.com/drugs/DB01007
    Approved

    Tioconazole interacts with 14-alpha demethylase, a cytochrome P-450 enzyme that converts lanosterol to ergosterol, an essential component of the yeast membrane. … Tioconazole is an imidazole antifungal used to treat fungal and yeast infections. Topical formulations are used for ringworm, jock itch, athlete's foot, and tinea versicolor or "sun fungus".

    Mixtures: GYNOMAX L VAJINAL OVUL, 7 ADET, Gynecure Com.pk.vag Ont6.5%vulvar Crm1% W/wCategories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP3A Inhibitors
  5. Drug

    Azaperone

    go.drugbank.com/drugs/DB11376
    InvestigationalVet approved

    Azaperone is a pyridinylpiperazine and butyrophenone agent that is capable of eliciting neuroleptic sedative and antiemetic effects. … It is subsequently employed predominantly as a veterinary tranquilizer and mainly for pigs and elephants.

    Synonyms: 1-(4-Fluorophenyl)-4-[4-(2-pyridinyl)-1-piperazinyl]-1-butanone, 1-(3-(4-Fluorobenzoyl)propyl)-4-(2-pyridyl)piperazine
  6. Drug

    Xylazine

    go.drugbank.com/drugs/DB11477
    InvestigationalVet approved

    Xylazine is a clonidine analog used as a non-opioid tranquilizer in veterinary medicine and as an emetic, especially in cats. … [A32545] Xylazine is not approved for human use and requires a veterinary licence for its purchase and use.

    Categories: Heterocyclic Compounds, 1-Ring, Adrenergic alpha-2 Receptor Agonists
  7. Drug

    Nesvategrast

    go.drugbank.com/drugs/DB19337
    Investigational

    Nesvategrast is under investigation in clinical trial NCT05409235 (Nesvategrast (OTT166) in Diabetic Retinopathy (DR)).

    Synonyms: (s)-3-(6-(difluoromethoxy)pyridin-3-yl)-3-(oxo-2-3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl)imidazolidin-1-yl)propanoate, 3-Pyridinepropanoic acid, 6-(difluoromethoxy)-β-[2-oxo-3-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-1-imidazolidinyl]-, (βS)-
  8. Drug

    Cicletanine

    go.drugbank.com/drugs/DB12766
    Investigational

    Cicletanine is under investigation for the treatment of Diabetes, Hypokalemia, Hyponatremia, and Arterial Hypertension.

    Categories: Heterocyclic Compounds, 1-Ring
  9. Drug

    Terpinen-4-ol

    go.drugbank.com/drugs/DB12816
    Investigational

    Terpinen-4-ol is under investigation in clinical trial NCT01647217 (Demodex Blepharitis Treatment Study).

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 SubstratesSynonyms: Terpinen-4-ol
  10. Drug

    Granotapide

    go.drugbank.com/drugs/DB12934
    Investigational

    Granotapide has been used in trials studying the treatment of Type II Diabetes Mellitus.