Desmoteplase

DB04925InvestigationalProtein Based Therapies

Desmoteplase is a chemical in the saliva of vampire bats. It activates plasminogen to the serine protease, plasmin. Plasmin acts by breaking down fibrin blood clots. When a vampire bat... When a vampire bat bites its victim, it secretes an enzyme that prevents the blood from clotting.

Mechanism: Desmoteplase targets and destroys fibrin, the structural scaffold of blood clots.
Curator reviewed
Primary indication: Investigated for use/treatment in cerebral ischemia and strokes.Curator reviewed
Also known as: DSPA desmoteplase · rDSPA alpha 1 · Salivary plasminogen activator alpha 1, Desmodus rotundus

Resolves to

Compound

UNIIT36L245S3TCAS145137-38-8

Targets

P00747PLG

What you can answer from here — as of June 15, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

644Drug interactionsStructured to mechanism, not free text

6Clinical trialsPhase, status and sponsor resolved per trial

10+ReferencesStructured and connected to the statements they support

Which drugs share a target with Desmoteplase, and which of those have an active Phase 3 trial?

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