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Macitentan
go.drugbank.com/drugs/DB08932ApprovedInvestigationalA combination product (Opsynvi) comprising macitentan and [tadalafil] was approved in Canada in October 2021 for the treatment of PAH.[L39105] It was subsequently approved by the FDA in March 2024. … [L35890] It was first approved by the FDA in 2013. Macitentan differs from its predecessor [bosentan] in part due to its lower risk of hepatotoxicity.
Mixtures: OPSYNVI® (MACITENTAN/TADALAFILO) 10MG/40 MG TABLETAS RECUBIERTASCategories: macitentan and tadalafilOlaparib
go.drugbank.com/drugs/DB09074ApprovedInvestigational[L41100, L40908, L43792] It was first approved by the FDA and EU in December 2014,[A246020] and by Health Canada in April 2016.[L42820] … [L41100, L40908, L43792] PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell
Categories: Antineoplastic and Immunomodulating AgentsProducts: LYNPARZA FILM-COATED TABLET 100MG, LYNPARZA FILM-COATED TABLET 150MGAmpicillin
go.drugbank.com/drugs/DB00415ApprovedInvestigationalVet approvedAmpicillin is a semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic.
Mixtures: BACTAMED 500MG/250MG I.M. ENJEKSIYONLUK TOZ IÇEREN FLAKON ,FLAKON, 1 ADET, Ampicillin and SulbactamProducts: Nu-ampi Capsules 250mg, Nu-ampi Suspension 250mg/5mlVincristine
go.drugbank.com/drugs/DB00541ApprovedInvestigationalVincristine is an antitumor vinca alkaloid isolated from Vinca Rosea. … because of lack of significant bone–marrow suppression (at recommended doses) and of unique clinical toxicity (neuropathy).
Categories: Antineoplastic and Immunomodulating AgentsProducts: VINCRISTINA INYECTABLE 2MG, VINRACINE INJECTION 1MG/1MLEntecavir
go.drugbank.com/drugs/DB00442ApprovedInvestigationalIt was approved by the U.S. Food and Drug Administration (FDA) in March 2005. … and adefovir).
Categories: Nucleosides and Nucleotides, Nucleoside and Nucleotide Reverse Transcriptase InhibitorsProducts: BARACLUDE 1MG, ENTECAVIR AL 1MGAlprazolam
go.drugbank.com/drugs/DB00404ApprovedIllicitInvestigational[L34783, L34788] It is mainly metabolized by CYP3As and so is contraindicated with CYP3A inhibitors like ketoconazole and itraconazole. … [L34783, L34788] Benzodiazepine treatment should be stopped gradually by tapering down a patient's dose to avoid withdrawal symptoms.
Categories: Hypnotics and Sedatives, Benzodiazepines and benzodiazepine derivativesProducts: Nu-alpraz Tab 0.5mg, Nu-alpraz Tab 0.25mgPropafenone
go.drugbank.com/drugs/DB01182ApprovedInvestigationalAn antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity. The drug is generally well tolerated.
Products: Nu-propafenone, RYTMONORM 150MGAnethole trithione
go.drugbank.com/drugs/DB13853Approvedinhibit carcinogenesis by increasing the activity of electrophile detoxification enzymes [A32619], and even being used as an adjunctive therapy for cholecystitis, gallstone, indigestion, and acute/chronic … Anethole trithione (ATT) appears to have a broad range of unique functions, from increasing salivary secretion to help treat xerostomia [A27165, A32618, A32620, A32621], to demonstrating an ability to
Categories: Alimentary Tract and Metabolism, Various Alimentary Tract and Metabolism ProductsProducts: Sialor Tab 25mgNetilmicin
go.drugbank.com/drugs/DB00955ApprovedNetilmicin is a semisynthetic 1-N-ethyl derivative of sisomycin, an aminoglycoside antibiotic with action similar to gentamicin, but less ear and kidney toxicity. … Netilmicin inhibits protein synthesis in susceptible organisms by binding to the bacterial 30S ribosomal subunit and interfering with mRNA binding and the acceptor tRNA site.
Synonyms: 1-N-EthylsisomicinProducts: Netromycin Inj 100mg/ml, LOTIFAR 150MG/2ML INJECTIONMinoxidil
go.drugbank.com/drugs/DB00350ApprovedInvestigationalA potent direct-acting peripheral vasodilator (vasodilator agents) that reduces peripheral resistance and produces a fall in blood pressure.
Categories: Skin and Mucous Membrane Agents, Arteriolar Smooth Muscle, Agents Acting OnProducts: Apo-gain Liq 20mg/ml, Loniten 10mg