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Entecavir
Identification
- Name
- Entecavir
- Accession Number
- DB00442
- Description
Entecavir is an oral antiviral drug used in the treatment of hepatitis B infection. It is marketed under the trade name Baraclude (BMS).
Entecavir is a guanine analogue that inhibits all three steps in the viral replication process, and the manufacturer claims that it is more efficacious than previous agents used to treat hepatitis B (lamivudine and adefovir). It was approved by the U.S. Food and Drug Administration (FDA) in March 2005.
- Type
- Small Molecule
- Groups
- Approved, Investigational
- Structure
Structure for Entecavir (DB00442)
- Weight
- Average: 277.2792
Monoisotopic: 277.117489371 - Chemical Formula
- C12H15N5O3
- Synonyms
- Anhydrous entecavir
- Entecavir
- Entecavir (anhydrous)
- Entecavir anhydrous
- Entecavirum
- External IDs
- BMS-200475-01
- ETV
- SQ34676
Pharmacology
- Indication
For the treatment of chronic hepatitis B virus infection in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease.
- Associated Conditions
- Contraindications & Blackbox Warnings
Learn about our commercial Contraindications & Blackbox Warnings data.
Learn More- Pharmacodynamics
Entecavir is a guanosine nucleoside analogue with selective activity against hepatitis B virus (HBV). It is designed to selectively inhibit the Hepatitis B virus, blocking all three steps in the replication process. Entecavir is more efficient than an older Hepatitis B drug, lamivudine.
- Mechanism of action
By competing with the natural substrate deoxyguanosine triphosphate, entecavir functionally inhibits all three activities of the HBV polymerase (reverse transcriptase, rt): (1) base priming, (2) reverse transcription of the negative strand from the pregenomic messenger RNA, and (3) synthesis of the positive strand of HBV DNA. Upon activation by kinases, the drug can be incorporated into the DNA which has the ultimate effect of inhibiting the HBV polymerase activity.
Target Actions Organism ADNA otherHumans - Absorption
Absorption Following oral administration in healthy subjects, entecavir peak plasma concentrations occurred between 0.5 and 1.5 hours. In healthy subjects, the bioavailability of the tablet is 100% relative to the oral solution.
- Volume of distribution
- Not Available
- Protein binding
Binding of entecavir to human serum proteins in vitro is approximately 13%.
- Metabolism
Entecavir is not a substrate, inhibitor, or inducer of the cytochrome P450 (CYP450) enzyme system. Entecavir is efficiently phosphorylated to the active triphosphate form.
- Route of elimination
- Not Available
- Half-life
After reaching peak concentration, entecavir plasma concentrations decreased in a bi-exponential manner with a terminal elimination half-life of approximately 128-149 hours. The phosphorylated metabolite has a half-life of 15 hours.
- Clearance
- renal cl=383.2 +/- 101.8 mL/min [Unimpaired renal function]
- renal cl=197.9 +/- 78.1 mL/min [Mild impaired renal function]
- renal cl=135.6 +/- 31.6 mL/min [Moderate impaired renal function]
- renal cl=40.3 +/- 10.1 mL/min [severe impaired renal function]
- apparent oral cl=588.1 +/- 153.7 mL/min [Unimpaired renal function]
- apparent oral cl=309.2 +/- 62.6 mL/min [Mild impaired renal function]
- apparent oral cl=226.3 +/- 60.1 mL/min [Moderate impaired renal function]
- apparent oral cl=100.6 +/- 29.1 mL/min [severe impaired renal function]
- apparent oral cl=50.6 +/- 16.5 mL/min [severe impaired renal function amnaged with Hemodialysis]
- apparent oral cl=35.7 +/- 19.6 mL/min [severe impaired renal function amnaged with CAPD]
- Adverse Effects
Learn about our commercial Adverse Effects data.
Learn More- Toxicity
Healthy subjects who received single entecavir doses up to 40 mg or multiple doses up to 20 mg/day for up to 14 days had no increase in or unexpected adverse events. If overdose occurs, the patient must be monitored for evidence of toxicity, and standard supportive treatment applied as necessary.
- Affected organisms
- Hepatitis B virus
- Pathways
- Not Available
- Pharmacogenomic Effects/ADRs
- Not Available
Interactions
- Drug Interactions
- This information should not be interpreted without the help of a healthcare provider. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The absence of an interaction does not necessarily mean no interactions exist.
Drug Interaction Unlock Additional DataAbametapir The serum concentration of Entecavir can be increased when it is combined with Abametapir. Abatacept The metabolism of Entecavir can be increased when combined with Abatacept. Abiraterone The serum concentration of Entecavir can be increased when it is combined with Abiraterone. Acenocoumarol The metabolism of Acenocoumarol can be decreased when combined with Entecavir. Acetaminophen The metabolism of Entecavir can be decreased when combined with Acetaminophen. Acyclovir The metabolism of Acyclovir can be decreased when combined with Entecavir. Adalimumab The metabolism of Entecavir can be increased when combined with Adalimumab. Adenovirus type 7 vaccine live The therapeutic efficacy of Adenovirus type 7 vaccine live can be decreased when used in combination with Entecavir. Agomelatine The metabolism of Agomelatine can be decreased when combined with Entecavir. Albendazole The metabolism of Albendazole can be decreased when combined with Entecavir. Additional Data Available- Extended DescriptionExtended Description
Extended description of the mechanism of action and particular properties of each drug interaction.
Learn more - Severity
- Evidence Level
- ActionAction
An effect category for each drug interaction. Know how this interaction affects the subject drug.
Learn more
- Food Interactions
- Take on an empty stomach. Take 2 hours before or 2 hours after a meal.
Products
- Product Ingredients
Ingredient UNII CAS InChI Key Entecavir monohydrate 5968Y6H45M 209216-23-9 YXPVEXCTPGULBZ-WQYNNSOESA-N Entecavir triphosphate Not Available Not Available ZTWBIZVVFNIRSF-HAFWLYHUSA-N - Product Images
- International/Other Brands
- Barcavir (Incepta) / Caavirel (PMP) / Entaliv (Dr. Reddy's Laboratories) / Teviral (ACI)
- Brand Name Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Unlock Additional DataBaraclude Tablet, film coated 1 mg Oral Bristol Myers Squibb Pharma Eeig 2006-06-26 Not applicable EU 
Baraclude Solution 0.05 mg/1mL Oral E.R. Squibb & Sons, L.L.C. 2005-03-29 Not applicable US 
Baraclude Tablet, film coated 0.5 mg Oral Bristol Myers Squibb Pharma Eeig 2006-06-26 Not applicable EU Baraclude Tablet, film coated 0.5 mg Oral Bristol Myers Squibb Pharma Eeig 2006-06-26 Not applicable EU Baraclude Tablet, film coated 0.5 mg Oral Bristol Myers Squibb Pharma Eeig 2006-06-26 Not applicable EU Baraclude Tablet, film coated 1.0 mg/1 Oral E.R. Squibb & Sons, L.L.C. 2005-03-29 Not applicable US Baraclude Tablet, film coated 0.5 mg/1 Oral E.R. Squibb & Sons, L.L.C. 2005-03-29 Not applicable US Baraclude Tablet 0.5 mg Oral Bristol Myers Squibb 2006-09-12 Not applicable Canada 
Baraclude Solution 0.05 mg/ml Oral Bristol Myers Squibb Pharma Eeig 2006-06-26 Not applicable EU Baraclude Tablet, film coated 1 mg Oral Bristol Myers Squibb Pharma Eeig 2006-06-26 Not applicable EU Additional Data Available- Application NumberApplication Number
A unique ID assigned by the FDA when a product is submitted for approval by the labeller.
Learn more - Product CodeProduct Code
A governmentally-recognized ID which uniquely identifies the product within its regulatory market.
Learn more
- Generic Prescription Products
Name Dosage Strength Route Labeller Marketing Start Marketing End Region Image Unlock Additional DataAccel-entecavir Tablet Oral Accel Pharma Inc 2020-03-11 Not applicable Canada Apo-entecavir Tablet Oral Apotex Corporation 2013-01-18 Not applicable Canada Auro-entecavir Tablet Oral Auro Pharma Inc 2015-12-01 Not applicable Canada Entecavir Tablet, film coated 1 mg/1 Oral Sunshine Lake Pharma Co., Ltd. 2020-05-20 Not applicable US Entecavir Tablet, film coated 1.0 mg/1 Oral Par Pharmaceutical 2014-08-18 2017-08-31 US Entecavir Tablet, film coated 1 mg/1 Oral Zydus Pharmaceuticals (USA) Inc. 2017-08-10 Not applicable US Entecavir Tablet, film coated 0.5 mg/1 Oral Teva Pharmaceuticals USA, Inc. 2014-09-04 2021-04-30 US Entecavir Tablet, film coated 1 mg/1 Oral Northstar RxLLC 2017-06-15 Not applicable US Entecavir Tablet, film coated 0.5 mg/1 Oral Cipla USA Inc. 2016-12-06 Not applicable US Entecavir Tablet, film coated 0.5 mg/1 Oral Marlex Pharmaceuticals Inc 2016-03-01 Not applicable US Additional Data Available- Application NumberApplication Number
A unique ID assigned by the FDA when a product is submitted for approval by the labeller.
Learn more - Product CodeProduct Code
A governmentally-recognized ID which uniquely identifies the product within its regulatory market.
Learn more
Categories
- ATC Codes
- J05AF10 — Entecavir
- Drug Categories
- Anti-Infective Agents
- Antiinfectives for Systemic Use
- Antiviral Agents
- Antivirals for Systemic Use
- Cytochrome P-450 CYP1A2 Substrates
- Cytochrome P-450 Substrates
- Direct Acting Antivirals
- Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor
- Heterocyclic Compounds, Fused-Ring
- Nucleoside and Nucleotide Reverse Transcriptase Inhibitors
- Nucleoside Reverse Transcriptase Inhibitors
- Nucleosides and Nucleotides
- Purines
- Purinones
- Chemical TaxonomyProvided by Classyfire
- Description
- This compound belongs to the class of organic compounds known as nucleoside and nucleotide analogues. These are analogues of nucleosides and nucleotides. These include phosphonated nucleosides, C-glycosylated nucleoside bases, analogues where the sugar unit is a pyranose, and carbocyclic nucleosides, among others.
- Kingdom
- Organic compounds
- Super Class
- Nucleosides, nucleotides, and analogues
- Class
- Nucleoside and nucleotide analogues
- Sub Class
- Not Available
- Direct Parent
- Nucleoside and nucleotide analogues
- Alternative Parents
- Hypoxanthines / 6-oxopurines / Pyrimidones / Aminopyrimidines and derivatives / N-substituted imidazoles / Cyclopentanols / Vinylogous amides / Heteroaromatic compounds / Cyclic alcohols and derivatives / Azacyclic compounds show 5 more
- Substituents
- 6-oxopurine / Alcohol / Amine / Aminopyrimidine / Aromatic heteropolycyclic compound / Azacycle / Azole / Cyclic alcohol / Cyclopentanol / Heteroaromatic compound show 20 more
- Molecular Framework
- Aromatic heteropolycyclic compounds
- External Descriptors
- secondary alcohol, oxopurine, primary alcohol, 2-aminopurines (CHEBI:473990)
Chemical Identifiers
- UNII
- NNU2O4609D
- CAS number
- 142217-69-4
- InChI Key
- QDGZDCVAUDNJFG-FXQIFTODSA-N
- InChI
- InChI=1S/C12H15N5O3/c1-5-6(3-18)8(19)2-7(5)17-4-14-9-10(17)15-12(13)16-11(9)20/h4,6-8,18-19H,1-3H2,(H3,13,15,16,20)/t6-,7-,8-/m0/s1
- IUPAC Name
- 2-amino-9-[(1S,3R,4S)-4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl]-6,9-dihydro-3H-purin-6-one
- SMILES
References
- Synthesis Reference
- US5206244
- General References
- Not Available
- External Links
- Human Metabolome Database
- HMDB0014585
- KEGG Drug
- D04008
- PubChem Compound
- 153941
- PubChem Substance
- 46504864
- ChemSpider
- 135679
- 1546027
- ChEBI
- 473990
- ChEMBL
- CHEMBL713
- ZINC
- ZINC000003802690
- Therapeutic Targets Database
- DAP000697
- PharmGKB
- PA164784025
- RxList
- RxList Drug Page
- Drugs.com
- Drugs.com Drug Page
- Wikipedia
- Entecavir
- AHFS Codes
- 08:18.32 — Nucleosides and Nucleotides
- FDA label
- Download (628 KB)
Clinical Trials
- Clinical Trials
Phase Status Purpose Conditions Count 4 Active Not Recruiting Prevention Exposure to Hepatitis B Virus / Reactivation of hepatitis B virus infection / Rheumatoid Arthritis 1 4 Active Not Recruiting Treatment Hepatitis B Chronic Infection 4 4 Active Not Recruiting Treatment Liver Cirrhosis / Viral Hepatitis B 1 4 Active Not Recruiting Treatment Viral Hepatitis B 1 4 Completed Prevention Non-Hodgkin's Lymphoma (NHL) / Viral Hepatitis B 1 4 Completed Treatment Chronic Viral Hepatitis B Without Delta-agent 2 4 Completed Treatment Fibrosis, Liver 1 4 Completed Treatment HBeAg-Positive Chronic Hepatitis B 1 4 Completed Treatment Hepatitis B Chronic Infection 18 4 Completed Treatment Hepatitis B Infection 1
Pharmacoeconomics
- Manufacturers
- Bristol myers squibb
- Packagers
- Bristol-Myers Squibb Co.
- E.R. Squibb and Sons LLC
- Dosage Forms
Form Route Strength Tablet Oral Tablet, film coated 0.5 mg Tablet, film coated 1 mg Solution Oral 0.05 mg/1mL Solution Oral 0.05 mg/ml Tablet Oral 0.5 mg Tablet, film coated Oral 0.5 mg Tablet, film coated Oral 1 mg Tablet, film coated Oral 1.0 MG Tablet, coated Oral 0.5 mg Tablet, coated Oral 1 mg Tablet Tablet Oral 0.5 mg/1 Tablet Oral 1 mg/1 Tablet, coated Oral 0.5 mg/1 Tablet, coated Oral 1 mg/1 Tablet, film coated Oral 0.5 mg/1 Tablet, film coated Oral 1 mg/1 Tablet, film coated Oral 1.0 mg/1 Tablet, coated 0.5 MG Tablet, coated 1 MG - Prices
Unit description Cost Unit Baraclude 0.5 mg tablet 28.94USD tablet Baraclude 1 mg tablet 28.94USD tablet DrugBank does not sell nor buy drugs. Pricing information is supplied for informational purposes only.- Patents
Patent Number Pediatric Extension Approved Expires (estimated) Region Unlock Additional DataCA2053339 No 2001-05-29 2011-10-11 Canada US5206244 Yes 1993-04-27 2015-08-21 US Additional Data Available- Filed On
Properties
- State
- Solid
- Experimental Properties
Property Value Source water solubility Slightly soluble (2.4 mg/mL at pH 7.9, 25 °C) Not Available logP -0.8 Not Available - Predicted Properties
Property Value Source Water Solubility 6.59 mg/mL ALOGPS logP -0.81 ALOGPS logP -1.4 ChemAxon logS -1.6 ALOGPS pKa (Strongest Acidic) 8 ChemAxon pKa (Strongest Basic) 2.77 ChemAxon Physiological Charge 0 ChemAxon Hydrogen Acceptor Count 7 ChemAxon Hydrogen Donor Count 4 ChemAxon Polar Surface Area 125.76 Å2 ChemAxon Rotatable Bond Count 2 ChemAxon Refractivity 71 m3·mol-1 ChemAxon Polarizability 27.31 Å3 ChemAxon Number of Rings 3 ChemAxon Bioavailability 1 ChemAxon Rule of Five Yes ChemAxon Ghose Filter No ChemAxon Veber's Rule No ChemAxon MDDR-like Rule No ChemAxon - Predicted ADMET Features
Property Value Probability Human Intestinal Absorption + 1.0 Blood Brain Barrier + 0.873 Caco-2 permeable - 0.7601 P-glycoprotein substrate Substrate 0.5802 P-glycoprotein inhibitor I Non-inhibitor 0.863 P-glycoprotein inhibitor II Non-inhibitor 0.9185 Renal organic cation transporter Non-inhibitor 0.8465 CYP450 2C9 substrate Non-substrate 0.8817 CYP450 2D6 substrate Non-substrate 0.8164 CYP450 3A4 substrate Non-substrate 0.5346 CYP450 1A2 substrate Non-inhibitor 0.7641 CYP450 2C9 inhibitor Non-inhibitor 0.848 CYP450 2D6 inhibitor Non-inhibitor 0.915 CYP450 2C19 inhibitor Non-inhibitor 0.87 CYP450 3A4 inhibitor Non-inhibitor 0.9647 CYP450 inhibitory promiscuity Low CYP Inhibitory Promiscuity 0.9552 Ames test Non AMES toxic 0.7523 Carcinogenicity Non-carcinogens 0.8026 Biodegradation Not ready biodegradable 0.9669 Rat acute toxicity 2.3879 LD50, mol/kg Not applicable hERG inhibition (predictor I) Weak inhibitor 0.8865 hERG inhibition (predictor II) Non-inhibitor 0.9062
Spectra
- Mass Spec (NIST)
- Not Available
- Spectra
Spectrum Spectrum Type Splash Key Predicted GC-MS Spectrum - GC-MS Predicted GC-MS Not Available Predicted MS/MS Spectrum - 10V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Positive (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 10V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 20V, Negative (Annotated) Predicted LC-MS/MS Not Available Predicted MS/MS Spectrum - 40V, Negative (Annotated) Predicted LC-MS/MS Not Available
Targets
Yes
Other
References
- Sims KA, Woodland AM: Entecavir: a new nucleoside analog for the treatment of chronic hepatitis B infection. Pharmacotherapy. 2006 Dec;26(12):1745-57. [PubMed:17125436]
- Walsh AW, Langley DR, Colonno RJ, Tenney DJ: Mechanistic characterization and molecular modeling of hepatitis B virus polymerase resistance to entecavir. PLoS One. 2010 Feb 12;5(2):e9195. doi: 10.1371/journal.pone.0009195. [PubMed:20169198]
Drug created on June 13, 2005 07:24 / Updated on September 27, 2020 08:17
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