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Brivudine
go.drugbank.com/drugs/DB03312ApprovedInvestigationalAlthough not approved in the U.S. or Canada, it is approved in several European countries.
Categories: Heterocyclic Compounds, 1-RingSynonyms: (E)-5-(2-Bromovinyl)-deoxyuridineCephalosporin C
go.drugbank.com/drugs/DB03313ExperimentalCategories: Heterocyclic Compounds, 2-RingSynonyms: 7-(5-Amino-5-carboxyvaleramido)cephalosporanic acid, Cephalosporin CGuanosine 3'-monophosphate
go.drugbank.com/drugs/DB03315ExperimentalCategories: Heterocyclic Compounds, 2-RingSynonyms: 3'-GMP, 3'-Guanylic acidTetramisole
go.drugbank.com/drugs/DB16561InvestigationalTetramisole is an anthelmintic agent.
Categories: Heterocyclic Compounds, 1-RingAlmonertinib
go.drugbank.com/drugs/DB16640ApprovedInvestigational[A231859, A231864, A231869] Unlike other third-generation EGFR TKIs, almonertinib is a pyrimidine-based drug that forms a covalent bond to the binding site of the EGFR tyrosine kinase domain. … Almonertinib is a third-generation EGFR tyrosine kinase inhibitor targeting EGFR-sensitizing and T790M resistance mutations.
Categories: MATE 1 Inhibitors, P-glycoprotein inhibitorsSynonyms: 2-Propenamide, N-[5-[[4-(1-cyclopropyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxyphenyl]-, N-[5-[[4-(1-Cyclopropyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxyphenyl]-2-propenamideRemibrutinib
go.drugbank.com/drugs/DB16852ApprovedInvestigational[L54101] Bruton's tyrosine kinase plays a role in B cell receptor and Fc receptor signalling, releasing histamine and pro-inflammatory mediators. … Remibrutinib is a selective Bruton's tyrosine kinase inhibitor. The FDA approved remibrutinib on September 30, 2025 as the only oral, targeted treatment for chronic spontaneous urticaria.
Categories: MATE 1 Inhibitors, P-glycoprotein inhibitorsTAK-418 free base
go.drugbank.com/drugs/DB16939InvestigationalSynonyms: 5-((1R,2R)-2-((Cyclopropylmethyl)amino)cyclopropyl)-N-(tetrahydro-2H-pyran-4-yl)thiophene-3-carboxamideCategories: Heterocyclic Compounds, 1-RingAZD2066
go.drugbank.com/drugs/DB17078InvestigationalSynonyms: Pyridine, 4-(5-((1r)-1-(5-(3-chlorophenyl)-3-isoxazolyl)ethoxy)-4-methyl-4h-1,2,4-triazol-3-yl)-Categories: Heterocyclic Compounds, 1-Ring, Receptor, Metabotropic Glutamate 5, antagonists & inhibitorsLinzagolix
go.drugbank.com/drugs/DB17083ApprovedInvestigationalLinzagolix is a non-peptide, selective antagonist of the gonadotropin-releasing hormone (GnRH) receptor. … [A253667] Linzagolix was approved for use in the European Union in June 2022 for the management of symptoms caused by uterine fibroids.[L43627]
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 InhibitorsSynonyms: 3-(5-((2,3-difluoro-6-methoxyphenyl)methoxy)-2-fluoro-4-methoxyphenyl)-2,4-dioxo-1,2,3,4-tetrahydrothieno(3,4-d)pyrimidine-5-carboxylic acid, Thieno(3,4-d)pyrimidine-5-carboxylic acid, 3-(5-((2,3-difluoro-6-methoxyphenyl)methoxy)-2-fluoro-4-methoxyphenyl)-1,2,3,4-tetrahydro-2,4-dioxo-