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Rivaroxaban
go.drugbank.com/drugs/DB06228ApprovedInvestigationalHowever there is no antidote available in the event of a major bleed. Only the 10 mg tablet can be taken without regard to food. The 15 mg and 20 mg tablet should be taken with food. … Rivaroxaban is an anticoagulant and the first orally active direct factor Xa inhibitor. Unlike warfarin, routine lab monitoring of INR is not necessary.
Categories: Factor Xa Inhibitors, Direct factor Xa inhibitorsProducts: RIVAROXABAN DR. REDDY'S, RIVAROXABAN EGLithium carbonate
go.drugbank.com/drugs/DB14509ApprovedInvestigationalLithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label].
Categories: Drugs that are Mainly Renally Excreted with a Narrow Therapeutic IndexProducts: Lithium Carbonate ERTreprostinil
go.drugbank.com/drugs/DB00374ApprovedInvestigationalHowever, the use of epoprostenol is limited due to its short half-life (3-5 min) and instability at room temperature. … [L41860] It is available in the following routes of administration: subcutaneous, intravenous, inhaled and oral. The first generic form of treprostinil became available in 2019.[A248775]
Products: TREPROSTINIL DR. REDDY'SParoxetine
go.drugbank.com/drugs/DB00715ApprovedInvestigational[L7712,L7715] A unique feature of this drug is that it is highly potent and selective in its inhibition of serotonin reuptake and has little effect on other neurotransmitters. … Paroxetine is well tolerated in most patients with a similar adverse effect profile to other members of its drug class.
Products: PAROXETINA EG, PAROXETINA EG STADASilodosin
go.drugbank.com/drugs/DB06207ApprovedInvestigationalSilodosin is a selective antagonist of alpha(α)-1 adrenergic receptors that binds to the α<sub>1A</sub> subtype with the highest affinity. α1-adrenergic receptors regulate smooth muscle tone in the bladder … neck, prostate, and prostatic urethra: the α<sub>1A</sub> subtype accounts for approximately 75% of α1-adrenoceptors in the prostate.
Categories: Drugs Used in Benign Prostatic HypertrophyProducts: SILODOSINA EG, SILODOSIN AL 4 MG HKPBortezomib
go.drugbank.com/drugs/DB00188ApprovedInvestigational[L14180] However, multiple mechanisms may be involved in the anticancer activity of bortezomib.[A204083] Bortezomib was first synthesized in 1995. … [A204083] The 26S proteasome is a protein complex that degrades ubiquitinated proteins in the ubiquitin-proteasome pathway: reversible inhibition of the 26S proteasome, leading to cell cycle arrest and
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic IndexSynonyms: N-[(1R)-1-(DIHYDROXYBORYL)-3-methylbutyl]-N-(pyrazin-2-ylcarbonyl)-L-phenylalaninamideDoxycycline
go.drugbank.com/drugs/DB00254ApprovedInvestigationalVet approvedDoxycycline is a broad-spectrum antibiotic synthetically derived from [oxytetracycline].[L42880] It is a second-generation tetracycline that was first discovered in 1967. … [A174034] Doxycycline is used to treat a wide variety of gram-positive and gram-negative bacterial infections. It is also used to treat acne and malaria.[A251730]
Products: ORACEA ® CAPSULAS DE LIBERACION MODIFICADA, LIEVRICIN-DSitagliptin
go.drugbank.com/drugs/DB01261ApprovedInvestigationalSitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256 … The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improve control of blood sugar[FDA label,A2255].
Mixtures: SITAGLIPTIN E METFORMINA GALENICUM, SITAGLIPTIN E METFORMINA GALENICUMCategories: Drugs Used in DiabetesRupatadine
go.drugbank.com/drugs/DB11614ApprovedInvestigationalRupatadine is a dual histamine H1 receptor and platelet activating factor receptor antagonist that is used for symptomatic relief in seasonal and perennial rhinitis as well as chronic spontaneous urticaria … It was approved for marketing in Canada under the tradename Rupall and comes in tablet formulation for adult use and liquid formulation for pediatric use.
Products: RUPATADINA EG, RUPATADIN AL 10 MG TABCyclobenzaprine
go.drugbank.com/drugs/DB00924ApprovedInvestigationalCyclobenzaprine, a centrally-acting muscle relaxant, was first synthesized in 1961[A185039] and has been available for human use since 1977. … [A184982] It was initially studied for use as antidepressant given its structural similarity to tricyclic antidepressants - it differs from [Amitriptyline] by only a single double bond.
Synonyms: N,N-dimethyl-5H-dibenzo(a,d)cycloheptene-Δ5,γ-propylamine, (3-Dibenzo[a,d]cyclohepten-5-ylidene-propyl)-dimethyl-amineProducts: Cyclobenzaprine HCL ER