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Human thrombin
go.drugbank.com/drugs/DB11571ApprovedInvestigationalIn particular, while human thrombin products are made from pooled human source plasma, recombinant thrombin is a human coagulation protein produced via recombinant DNA technology from a genetically modified … Chinese hamster ovary cell line [FDA Label].
Mixtures: EVICEL® SELLANTE DE FIBRINA HUMANAGlimepiride
go.drugbank.com/drugs/DB00222ApprovedInvestigationalCompared to [glipizide], another second SU drug, glimepiride has a longer duration of action. … It is sometimes classified as a third-generation SU because it has larger substitutions than other second-generation SUs.
Mixtures: GLIMETAL-DP, METGLITAL LEX 850/4 MG TABLETAS DE LIBERACIÓN PROLONGADAProducts: GLIMEPIRID 1A PHARMA 1MG, GLIMEPIRID 1A PHARMA 2MGMepyramine
go.drugbank.com/drugs/DB06691ApprovedVet approvedIt is a first generation antihistamine. However, it rapidly permeates the brain and so often causes drowsiness as a side effect.
Mixtures: Zotex-D, Deconsal DMGadoteric acid
go.drugbank.com/drugs/DB09132ApprovedInvestigational[A263141,A263106] Gadoterate is approved by the FDA under the brand name DOTAREM on 20th March 2013 for intravenous uses with magnetic resonance imaging (MRI) in the brain (intracranial), spine, and … due to a decreased tendency of gadolinium dechelation.
Categories: Compounds used in a research, industrial, or household settingVarenicline
go.drugbank.com/drugs/DB01273ApprovedInvestigationalA full agonism was displayed on alpha7-receptors. On March 9, 2015, the U.S. … The FDA said it is keeping the black box in place at least until the results of the trial are announced.
Flupentixol
go.drugbank.com/drugs/DB00875ApprovedInvestigationalWithdrawn[A229083] Flupentixol is an antagonist of both D1 and D2 dopamine receptors. … It is used for the management of chronic schizophrenia in patients whose main manifestations do not include excitement, agitation or hyperactivity.
Categories: Dopamine D2 Receptor AntagonistsAzacitidine
go.drugbank.com/drugs/DB00928ApprovedInvestigationalThe other one is through the inhibition of DNA methyltransferase, impairing DNA methylation. … As an analogue of cytidine, it is able to incorporate into RNA and DNA, disrupting RNA metabolism and inhibiting protein and DNA synthesis.
Synonyms: 4-amino-1-beta-D-ribofuranosyl-s-triazin-2(1H)-oneAngiotensin II
go.drugbank.com/drugs/DB11842ApprovedInvestigationaloptions for critically ill hypotensive patients who do not adequately respond to currently available therapies. … As of December 21, 2017 the FDA approved La Jolla Pharmaceutical's Giapreza (angiotensin II) Injection for Intravenouse Infusion for the indication of acting as a vasoconstrictor to increase blood pressure
Durvalumab
go.drugbank.com/drugs/DB11714ApprovedInvestigational[A192789,L12627] On March 27, 2020, durvalumab was approved by the FDA for use in combination with [etoposide] and either [carboplatin] or [cisplatin] as first-line treatment of patients with extensive-stage … [A192789] Produced by recombinant DNA technology in Chinese Hamster Ovary (CHO) cell suspension culture,[L12621] durvalumab is a programmed death-ligand 1 (PD-L1) blocking antibody that works to promote
Rezafungin
go.drugbank.com/drugs/DB16310ApprovedInvestigational[A258403] In March 2023, the FDA approved rezafungin for injection for the treatment of candidemia and invasive candidiasis in adults with limited or no alternative treatment options. … Rezafungin has a half-life higher than 130 hours and can be administered once a week instead of daily.