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Ibritumomab tiuxetan
go.drugbank.com/drugs/DB00078ApprovedIbritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light chains of 213 amino acids each. … Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes.
Categories: Lymphoma, B-CellProducts: ZEVAMAB®Pegvisomant
go.drugbank.com/drugs/DB00082ApprovedInvestigationalPegvisomant is a highly selective growth hormone (GH) receptor antagonist. It is used to treat acromegaly. … Unlike dopamine or somatostatin analogs (which inhibit growth hormone secretion), this drug actually blocks the hepatic (GH-mediated) production of insulin like growth factor (IGF-1), which is the main
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersProducts: SOMAVERT® 15 MG POLVO LIOFILIZADO PARA SOLUCIÓN INYECTABLE, SOMAVERT ®10MG POLVO LIOFILIZADO PARA SOLUCIÓN INYECTABLEBotulinum toxin type A
go.drugbank.com/drugs/DB00083ApprovedInvestigationalIn 2002, botulinum toxin A, also known as onabotulinumtoxinA or Botox, was the first type A botulism toxin to be introduced into the market for cosmetic use. … [A231824] With a wide variety of applications and favourable safety profile, Botulinum toxin A injection is a minimally invasive and promising treatment for cosmetic imperfections, muscle spasms, and other
Categories: Botulinum Toxins, Type ASynonyms: BTX A, BTX-AAlglucerase
go.drugbank.com/drugs/DB00088ApprovedWithdrawnHuman Beta-glucocerebrosidase or Beta-D-glucosyl-N-acylsphingosine glucohydrolase E.C. 3.2.1.45. 497 residue protein with N-linked carbohydrates, MW=59.3 kD. … The modification alters the sugar residues at the non-reducing ends of the oligosaccharide chains of the glycoprotein so that they are predominantly terminated with mannose residues.
Laronidase
go.drugbank.com/drugs/DB00090ApprovedInvestigationalLaronidase is a glycoprotein with a molecular weight of approximately 83 kD. … The predicted amino acid sequence of the recombinant form, as well as the nucleotide sequence that encodes it, are identical to a polymorphic form of human a-L-iduronidase.
Synonyms: alpha-L-Idosiduronase, Human Recombinant alpha-L-iduronidaseProducts: ALDURAZYME ®, ALDURAZYME 100 U/ML IV INFUZYON ICIN KONSANTRE COZELTI, 1 ADETEfalizumab
go.drugbank.com/drugs/DB00095ApprovedWithdrawnEfalizumab has a molecular weight of approximately 150 kilodaltons and is produced in a Chinese hamster ovary mammalian cell expression system in a nutrient medium containing the antibiotic gentamicin. … It was later withdrawn in 2009 due to a potential risk of progressive multifocal leukoencephalopathy (PML).[L43797]
Products: RAPTIVA ®125 MGChoriogonadotropin alfa
go.drugbank.com/drugs/DB00097ApprovedInvestigationalThe primary structure of the alpha-chain of r-hCG is identical to that of the alpha-chain of hCG, FSH and LH. … Recombinant human chorionic gonadotropin with 2 subunits, alpha = 92 residues, beta = 145 residues, each with N-and O-linked carbohydrate moieties linked to ASN-52 and ASN-78 (on alpha subunit) and ASN
Products: OVITRELLE 250 MCG/0,5 ML KULLANIMA HAZIR ŞIRINGADA ENJEKSİYONLUK ÇÖZELTİ, 1 ADETAntithymocyte immunoglobulin (rabbit)
go.drugbank.com/drugs/DB00098ApprovedInvestigationalThymoglobulin is a mixture of antibodies intended to bind to various cell surface antigens. The most common mode of action of Thymoglobulin is via selective depletion of T-cells. … Thymoglobulin is a polyclonal antibody that suppresses certain types of immune cells responsible for acute organ rejection in transplant patients.
Categories: Immunoglobulin G, Increased T Lymphocyte DestructionSynonyms: r-ATG, Lapine T-lymphocyte immune globulinIpratropium
go.drugbank.com/drugs/DB00332ApprovedInvestigationalIpratropium is a quaternary ammonium derivative of [atropine][A176957] that acts as an anticholinergic agent. … [A176939] It is commonly administered through inhalation which allows producing a local effect without presenting a significant systemic absorption.
Mixtures: BERODUAL® HFA, BERODUAL® HFAProducts: Atrovent ® 0.025% Nebuliser Solution, BRIA®Phenylpropanolamine
go.drugbank.com/drugs/DB00397ApprovedVet approvedWithdrawnPhenylpropanolamine is a sympathomimetic agent that acts as a nonselective adrenergic receptor agonist and norepinephrine reuptake inhibitor. … It has been used as a decongestant and appetite suppressant. Currently, it is withdrawn from the market in Canada and the United States due to the risk for hemorrahgic strokes.
Mixtures: Sinutab Sa Tab, TERA FCategories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substrates, Adrenergic beta-2 Receptor Agonists