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Bisegliptin
go.drugbank.com/drugs/DB06127InvestigationalIt is an orally active, dipeptidyl peptidase-IV (DPPIV) inhibitor which lowers blood glucose levels by blocking the degradation of the hormone GLP-1 thereby stimulating glucose-dependent insulin secretion … Bisegliptin is a compound for the treatment of type 2 diabetes.
Lumefantrine co-artemether
go.drugbank.com/drugs/DB13085ApprovedInvestigationalWithdrawnThe combination is an effective and well-tolerated malaria treatment, providing high cure rates even in areas of multi-drug resistance. … The exact mechanism of action of lumefantrine is not well defined, but it is thought to inhibit -hematin formation, an important detoxification pathway for the parasite.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesAfelimomab
go.drugbank.com/drugs/DB04956ExperimentalAfelimomab (also known as Fab 2 or MAK 195F) is an anti-TNF-α monoclonal antibody. Administration of 195F reduces the concentration of interleukin-6 in patients with sepsis.
Interferon alfa-2b
go.drugbank.com/drugs/DB00105ApprovedInvestigationalIt is used extensively as an antiviral or antineoplastic agent. … A type I interferon consisting of 165 amino acid residues with arginine in position 23. This protein is produced by recombinant DNA technology and resembles interferon secreted by leukocytes.
Mixtures: Intron A, Intron ACategories: Interferon Type I, Cytochrome P-450 CYP1A2 InhibitorsSulfaphenazole
go.drugbank.com/drugs/DB06729ApprovedSulfaphenazole is a sulfonamide antibacterial.
Categories: Cytochrome P-450 CYP2B6 Inhibitors, Heterocyclic Compounds, 1-RingSynonyms: N(1)-(1-phenylpyrazol-5-yl)sulfanilamide, N'-(1-phenylpyrazol-5-yl)sulfanilamideNUC B1000
go.drugbank.com/drugs/DB05242ExperimentalNUC B1000 is an expressed interfering RNA (eiRNA)- based product consisting of a plasmid DNA construct designed to produce four short interfering RNA (siRNA) molecules, formulated with a proprietary cationic-lipid … [F3910] eiRNA is an approach to RNAi therapeutics, whereby a plasmid DNA coding for desired dsRNA is delivered to diseased cells enabling the cells to carry out dsRNA production internally thereby invoking
Meningococcal polysaccharide vaccine group A
go.drugbank.com/drugs/DB13889ApprovedInvestigationalIt is subcutaneously administered as an active immunization against the invasive meningococcal disease caused by the serogroup A. … *N. meningitidis* is a bacteria that causes endemic and epidemic diseases including meningitis and meningococcemia.
Synonyms: Neisseria meningitidis group A polysaccharide antigen, A, Meningococcal group A polysaccharideMixtures: Menomune - A/c/y/w-135 Combined, Menomune-A/c/y/w-135Meningococcal polysaccharide vaccine group C
go.drugbank.com/drugs/DB13890ApprovedInvestigationalIt is subcutaneously administered as an active immunization against the invasive meningococcal disease caused by the serogroup C. … *N. meningitidis* is a bacteria that causes endemic and epidemic diseases including meningitis and meningococcemia.
Synonyms: Meningococcal group C polysaccharide, Meningococcal polysaccharide antigen group CMixtures: Menomune - A/c/y/w-135 Combined, Menomune-A/c/y/w-135Remifentanil
go.drugbank.com/drugs/DB00899ApprovedInvestigationalRemifentanil (marketed by Abbott as Ultiva) is a potent ultra short-acting synthetic opioid given to patients during surgery for pain relief and adjunctive to an anaesthetic. … Remifentanil is a specific mu-type-opioid receptor agonist which means it reduces sympathetic nervous system tone, and causes respiratory depression and analgesia.
Categories: Heterocyclic Compounds, 1-RingProducts: Remifentanil Kabi 1 mg Pulver zur Herstellung eines Konzentrats für eine Injektions- oder Infusionslösung, Remifentanil Kabi 2 mg Pulver zur Herstellung eines Konzentrats für eine Injektions- oder InfusionslösungDiphenylpyraline
go.drugbank.com/drugs/DB01146ApprovedDiphenylpyraline is an antihistamine. Antihistamines used in the treatment of allergy act by competing with histamine for H 1-receptor sites on effector cells.
Synonyms: 1-methyl-4-piperidyl benzhydryl ether, 4-(benzhydryloxy)-1-methylpiperidineMixtures: Emercidin D Tab, Oradrine 2 Tab