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Displaying results 801 - 810 of 10000 in total
  1. Drug

    Loperamide

    go.drugbank.com/drugs/DB00836
    ApprovedInvestigational

    Loperamide is an anti-diarrheal agent that is available as an over-the-counter product for treating diarrhea.[L42785] The drug was first synthesized in 1969 and used medically in 1976. … [A251610] It is a highly lipophilic synthetic phenylpiperidine opioid that works by binding to mu-opioid receptors on intestinal muscles to decrease intestinal motility and electrolyte loss.

    Mixtures: Up and Up Anti Diarrheal Anti Gas, Doc in the Box All Day SupplyInternational brands: Kaopectate II
  2. Pathway

    Tamoxifen Anti-Cancer Action Pathway

    smpdb.ca/view/SMP0124698
    Drug action

    It competitively inhibits estrogen/estradiol binding to its receptor which prevents the coactivator from binding to the receptor-tamoxifen complex in the nucleus. … Tamoxifen is an anticancer drug that is a selective estrogen receptor modulator also known as a non-steroidal anti-estrogen.

    Drugs: Tamoxifen · Estradiol · Mesoheme · Flavin adenine dinucleotide · Uridine-5'-Diphosphate · Formaldehyde
    Enzymes: Steroid hormone receptor ERR1
  3. Indication

    Hypogonadism female

    go.drugbank.com/conditions/DBCOND0009292
    Drugs: Estradiol
  4. Indication

    Advanced androgen dependent Prostate cancer

    go.drugbank.com/conditions/DBCOND0022319
    Drugs: Estradiol
  5. Indication

    Female castration

    go.drugbank.com/conditions/DBCOND0126033
    Drugs: Estradiol
  6. Drug

    Goflikicept

    go.drugbank.com/drugs/DB16396
    Investigational

    Goflikicept is under investigation in clinical trial NCT04380519 (Study of the Efficacy and Safety of a Single Administration of Olokizumab and RPH-104 With Standard Therapy in Patients With Severe Severe

    Synonyms: Heterodimeric fusion protein that binds to IL-1 beta consisting of human extracellular domain of IL1 receptor and a mutant Fc fragment of human IGg1 and part of human IL1 receptor accessory protein
  7. Drug

    RAD 502

    go.drugbank.com/drugs/DB17328
    Experimental

    Synonyms: Lutetium-177 labeled humanized monoclonal antibody targeting leucine rich repeat containing 15 (LRRC15)
  8. Drug

    Ozekibart

    go.drugbank.com/drugs/DB18675
    Investigational

    Ozekibart is a tetravalent recombinant humanized IgG1 agonist antibody targeting the human TRAIL death receptor 5 (DR5). It is being investigated for the treatment of chondrosarcoma.

    Synonyms: Immunoglobulin, anti-(human death receptor 5) (human-Lama glama clone IF5 single-domain VHH fragment) fusion protein with peptide linker (GGS)2 fusion protein with immunoglobulin anti-(human death receptor, Tetravalent recombinant humanized IgG1 agonist antibody targeting the human TRAIL death receptor 5 (DR5).
  9. Drug

    Triclosan

    go.drugbank.com/drugs/DB08604
    Approved

    An aromatic ether that is phenol which is substituted at C-5 by a chloro group and at C-2 by a 2,4-dichlorophenoxy group. … It is widely used as a preservative and antimicrobial agent in personal care products such as soaps, skin creams, toothpaste and deodorants as well as in household items such as plastic chopping boards

    Mixtures: QV FLARE UP BATH OIL, QV Flare Up Bath OilProducts: Up (and) Up Green Apple Scent, Kay QSR
  10. Drug

    AGT-182

    go.drugbank.com/drugs/DB17630
    Investigational

    AGT-182 is an investigational enzyme replacement therapy engineered by the fusion of the iduronate-2-sulfatase (IDS) enzyme and a human insulin receptor monoclonal antibody.

    Synonyms: Recombinant human insulin receptor monoclonal antibody-fused iduronate 2-sulfatase