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Displaying results 801 - 810 of 2454 in total
  1. Drug

    Dichlorobenzene

    go.drugbank.com/drugs/DB14046
    ApprovedWithdrawn

    Dichlorobenzene refers to any of, or a mixture of, three isomers consisting of benzene in which two of the hydrogen atoms are replaced by chlorine atoms: ortho-, meta-, and paradichlorobenzene. It is a constituent of the ear-wax removal ...

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2E1 Substrates
  2. Drug

    (S)-Warfarin

    go.drugbank.com/drugs/DB14055
    Investigational

    Warfarin consists of a racemic mixture of two active enantiomers—R- and S- forms—each of which is cleared by different pathways. S-warfarin is 2-5 times more potent than the R-isomer in producing an anticoagulant response.

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C18 Substrates
  3. Drug

    Dexverapamil

    go.drugbank.com/drugs/DB14063
    Experimental

    Categories: P-glycoprotein inhibitors, Cytochrome P-450 Substrates
  4. Drug

    Emopamil

    go.drugbank.com/drugs/DB14064
    Experimental

    Prevents renal injury after warm & cold ischemia.

    Categories: P-glycoprotein inhibitors, Cytochrome P-450 Substrates
  5. Drug

    Lomerizine

    go.drugbank.com/drugs/DB14065
    Experimental

    Lomerizine is a diphenylmethylpiperazine calcium channel blocker with relatively selective central nervous system (CNS) effects. This drug is used to prophylactically treat migraines and is also being investigated against eye-related dis...

    Categories: P-glycoprotein inhibitors, Cytochrome P-450 Substrates
  6. Drug

    ONT-093

    go.drugbank.com/drugs/DB14069
    Experimental

    ONT-093 is an orally bioavailable inhibitor of P-glycoprotein (P-gp). … In pre-clinical studies, ONT-093 could inhibit P-gp and reverse multidrug resistance at nM concentrations with no effect on paclitaxel pharmacokinetics.

    Categories: P-glycoprotein inhibitors
  7. Drug

    Macelignan

    go.drugbank.com/drugs/DB14129
    Investigational

    Macelignan is an NSAID with antioxidant, free radical scavenging, and neuroprotective activities.

    Categories: P-glycoprotein inhibitors
  8. Drug

    8-chlorotheophylline

    go.drugbank.com/drugs/DB14132
    Experimental

    8-Chlorotheophylline is a stimulant drug of the xanthine chemical class, with physiological effects similar to caffeine. Its main use is in combination with Diphenhydramine as the antiemetic drug Dimenhydrinate. The stimulant properties ...

    Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 Substrates
  9. Drug

    Lorvotuzumab mertansine

    go.drugbank.com/drugs/DB12089
    Investigational

    Lorvotuzumab mertansine has been used in trials studying the treatment of SCLC, Leukemia, Ovarian Cancer, Multiple Myeloma, and Merkel Cell Carcinoma, among others.

    Categories: Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 CYP3A4 Inhibitors
  10. Drug

    Secoisolariciresinol

    go.drugbank.com/drugs/DB12179
    Investigational

    Secoisolariciresinol has been used in trials studying the prevention of Breast Cancer.

    Categories: P-glycoprotein inhibitors