8-Chlorotheophylline is a stimulant drug of the xanthine chemical class, with physiological effects similar to caffeine. Its main use is in combination with Diphenhydramine as the antiemetic drug Dimenhydrinate. The... The stimulant properties of 8-chlorotheophylline are thought to ward off the drowsiness caused by diphenhydramine's anti-histamine activity in the central nervous system.
- Mechanism
- Curator reviewed · 2 references
8-chlorotheophylline produces a number of effects including nervousness, restlessness, insomnia, headache, and nausea, which are primarily attributed to its ability to block the adenosine receptor. Because adenosine causes a decrease in neuronal firing, blockade of the adenosine receptor causes the reverse effect resulting in excitation.
- Primary indication
- When used in combination with DB01075 as the antiemetic DB00985, 8-chlorotheophylline is indicated for the prevention and treatment of nausea, vomiting, or vertigo of motion sickness.Curator reviewed
- Formula / weight
- C7H7ClN4O2 · 214.609 g/mol (avg)
- Also known as
- Chlorotheophylline · Chlortheophylline
Resolves to
RYIGNEOBDRVTHA-UHFFFAOYSA-NSMILESCN1C2=C(NC(Cl)=N2)C(=O)N(C)C1=OWhat you can answer from here — as of April 02, 2025
Which drugs share a target with 8-chlorotheophylline, and which of those have an active Phase 3 trial?
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