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Etelcalcetide
go.drugbank.com/drugs/DB12865ApprovedInvestigationalEtelcalcetide was approved (trade name Parsabiv) for the treatment of secondary hyperparathyroidism (HPT) in adult patients with chronic kidney disease (CKD) on hemodialysis in February, 2017. … Etelcalcetide is a calcimimetic drug for the treatment of secondary hyperparathyroidism in patients undergoing hemodialysis.
Products: PARSABIV SOLUTION FOR INJECTION 10 mg/2 mL, PARSABİV 10 MG/2 ML I.V. ENJEKSİYONLUK ÇÖZELTİ, 1 ADETNimodipine
go.drugbank.com/drugs/DB00393ApprovedInvestigationalIt acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. … Compared to other calcium channel blocking agents, nimodipine exhibits greater effects on cerebral circulation than on peripheral circulation.
Categories: Heterocyclic Compounds, 1-RingSynonyms: isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate, isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylateCyclobenzaprine
go.drugbank.com/drugs/DB00924ApprovedInvestigationalCyclobenzaprine, a centrally-acting muscle relaxant, was first synthesized in 1961[A185039] and has been available for human use since 1977. … [A185039,A184982] Since its approval, it has remained relatively popular as an adjunctive, short-term treatment for acute skeletal muscle spasms secondary to musculoskeletal injury.
Synonyms: N,N-dimethyl-5H-dibenzo(a,d)cycloheptene-Δ5,γ-propylamineMixtures: Cyclo/Gaba 10/300 Pack, Therabenzaprine-60Colistin
go.drugbank.com/drugs/DB00803ApprovedInvestigationalIt is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes.
Synonyms: Polymyxin EProducts: APSASOL COLISTIN Powder 100 mg/g, Poly-E Water Soluble Powder 750MIU/kgMethylprednisolone hemisuccinate
go.drugbank.com/drugs/DB14644ApprovedInvestigationalA water-soluble ester of methylprednisolone used for cardiac, allergic, and hypoxic emergencies.
Categories: Compounds used in a research, industrial, or household settingProducts: METILPREDNISOLON SOPHARMA 40 MG ENJEKSİYONLUK SOLÜSYON HAZIRLAMAK İÇİN LİYOFİLİZE TOZ İÇEREN AMPUL, 10 ADET, METICURE 20 MG IM/IV ENJEKSIYON ICIN LIYOFIZE TOZ ICEREN FLAKON, 1 ADETRizatriptan
go.drugbank.com/drugs/DB00953ApprovedInvestigationalRizatriptan is a second-generation triptan [A258918] and a selective 5-HT<sub>1B and 5-HT1D</sub> receptor agonist. … [L46018] Used in the treatment of migraines, rizatriptan was first approved in the US in 1998.
Synonyms: N,N-Dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]-ethanamine, N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamineCategories: Heterocyclic Compounds, 2-Ring, Serotonin-1b and Serotonin-1d Receptor AgonistImipramine
go.drugbank.com/drugs/DB00458ApprovedInvestigationalTCAs also block histamine H<sub>1</sub> receptors, α<sub>1</sub>-adrenergic receptors and muscarinic receptors, which accounts for their sedative, hypotensive and anticholinergic effects (e.g. blurred … They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depressed individuals, imipramine does not affect mood or arousal, but may cause sedation.
Categories: Adrenergic alpha-1 Receptor AntagonistsSynonyms: 10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine, N-(γ-dimethylaminopropyl)iminodibenzylMepivacaine
go.drugbank.com/drugs/DB00961ApprovedInvestigationalVet approvedMepivacaine is effective topically only in large doses and therefore should not be used by this route. (From AMA Drug Evaluations, 1994, p168)
Mixtures: 2% Polocaine Dental With Levonordefrin 1:20,000, MEPISEAL-ECategories: Heterocyclic Compounds, 1-RingPrednisone
go.drugbank.com/drugs/DB00635ApprovedInvestigationalVet approved[A187463] It is biologically inert and converted to [prednisolone] in the liver.[L10502] Prednisone was granted FDA approval on 21 February 1955.[L10496]
Synonyms: 1, 2-Dehydrocortisone, 1,4-Pregnadiene-17α,21-diol-3,11,20-trioneProducts: PredniSONE Tablets, USP, 20 mg, PredniSONE Tablets, USP, 10 mgVildagliptin
go.drugbank.com/drugs/DB04876ApprovedInvestigationalElevated levels of GLP-1 and GIP consequently results in improved glycemic control.[L32803] In clinical trials, vildagliptin has a relatively low risk of hypoglycemia. … [A232488] By inhibiting DPP-4, vildagliptin prevents the degradation of glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), which are incretin hormones that promote
Mixtures: VILMET 50 MG/1000 MG FILM KAPLI TABLET ,1TABLET, 20 ADET, VILMET 50 MG/850 MG FILM KAPLI TABLET ,1TABLET, 120 ADETCategories: Drugs Used in Diabetes, Glucagon-Like Peptide 1