Etelcalcetide

DB12865ApprovedInvestigationalSmall moleculeCalcium-sensing Receptor Agonist

Etelcalcetide is a calcium sensing receptor agonist used to treat secondary hyperparathyroidism in patients with chronic kidney disease who require hemodialysis. A medication used to treat a gland condition that develops in kidney disease, and high calcium in the blood.

Mechanism: Etelcalcetide is a calcimimetic agent that allosterically modulates the calcium-sensing receptor (CaSR). Etelcalcetide binds to the CaSR and enhances activation of the receptor by extracellular calcium. Activation of the CaSR on parathyroid chief cells decreases PTH secretion.
Curator reviewed
Primary indication: Etelcalcetide is a calcium-sensing receptor agonist indicated for: Secondary hyperparathyroidism (HPT) in adult patients with chronic kidney disease (CKD) on hemodialysis.Curator reviewed · 1 structured indication
Formula / weight: C₃₈H₇₃N₂₁O₁₀S₂ · 1048.26 g/mol (avg)
First approval: United States, 2017 · European Union, 2020
Also known as: Velcalcetide
Code names: AMG-416 · KAI-4169
Brand names: Parsabiv

Resolves to

Compound

UNII60ME133FJBCAS1262780-97-1ChEMBLCHEMBL3545184ChEBI134700PubChem71511839KEGGD10676

Clinical / RWD

RxNorm1876119ATCH05BX04

Structure

InChIKeyANIAZGVDEUQPRI-ZJQCGQFWSA-NSMILES

C[C@@H](NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](C)NC(=O)[C@@H](CSSC[C@H](N)C(O)=O)NC(C)=O)C(=O)N[C@H](CCCNC(N)=N)C(N)=O

Targets

P41180CASR

What you can answer from here — as of September 23, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

13Clinical trialsPhase, status and sponsor resolved per trial

1Structured indicationCondition, population, route and combination as fields, not prose

43Marketed productsAcross 7 countries and 5 labellers

1ATC codeIncluding every combination product, plus 6 drug categories

4+ReferencesStructured and connected to the statements they support

Which drugs share a target with Etelcalcetide, and which of those have an active Phase 3 trial?

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