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Apalutamide
go.drugbank.com/drugs/DB11901ApprovedInvestigationalIn a randomized trial, the median metastasis-free survival for patients taking apalutamide was 40.5 months compared to 16.2 months for patients taking a placebo [L1295]. … In a phase-2 multicenter open-label study, 89% of patients with non-metastatic, castration-resistant prostate cancer had ≥50% PSA decline at week 12 of apalutamide treatment [A31846].
Categories: MATE 1 Inhibitors, MATE 2 InhibitorsProducts: ERLEADA ®TABLETAS RECUBIERTAS 60 MGRociletinib
go.drugbank.com/drugs/DB11907InvestigationalRociletinib has been used in trials studying the treatment and prevention of Nonsmall Cell Lung Cancer, Non-small Cell Lung Cancer, and Locally Advanced or Metastatic Non-small Cell Lung Cancer.
Categories: Heterocyclic Compounds, 1-RingVarespladib
go.drugbank.com/drugs/DB11909InvestigationalVarespladib has been investigated for the treatment and prevention of Sickle Cell Disease, Vaso-occlusive Crisis, and Acute Coronary Syndrome.
Categories: Phospholipases A, antagonists & inhibitors, Heterocyclic Compounds, 2-RingLebrikizumab
go.drugbank.com/drugs/DB11914ApprovedInvestigationalLebrikizumab is a monoclonal antibody that binds to IL-13 with high affinity and slow off-rate.[L51374] It binds to a different epitope compared [tralokinumab]. … November 17, 2023, lebrikizumab was approved by the EMA under the brand name EBGLYSS for the treatment of moderate-to-severe atopic dermatitis in adult and adolescent patients 12 years and older with a
Valbenazine
go.drugbank.com/drugs/DB11915ApprovedInvestigational[A261165] However, challenges in using [tetrabenazine] as a treatment of tardive dyskinesia included frequent dosing and safety and tolerability concerns. … [L47885,A261135] Tardive dyskinesia has long been regarded as a consequence of anti-dopamine receptor therapy, and until 2008 with the advent of [tetrabenazine], most treatments were ineffective.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: REMLEAS™ hard capsules 40mgGuadecitabine
go.drugbank.com/drugs/DB11918InvestigationalGuadecitabine is under investigation for the treatment of Previously Treated Metastatic Colorectal Cancer.
Categories: Heterocyclic Compounds, 1-Ring6-O-benzylguanine
go.drugbank.com/drugs/DB11919Investigational6-O-benzylguanine has been used in trials studying the treatment of HIV Infection, Adult Gliosarcoma, Adult Glioblastoma, Stage I Adult Hodgkin Lymphoma, and Stage II Adult Hodgkin Lymphoma, among others
Synonyms: O(6)-BenzylguanineCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesLesogaberan
go.drugbank.com/drugs/DB11920InvestigationalLesogaberan has been used in trials studying the treatment and basic science of GERD, Reflux, Heartburn, Regurgitation, and Reflux Disease, among others.
Categories: GABA-A Receptor AgonistsSafingol
go.drugbank.com/drugs/DB11924InvestigationalSafingol has been used in trials studying the treatment of Unspecified Adult Solid Tumor, Protocol Specific.
Categories: Protein Kinase C, antagonists & inhibitorsEpelsiban
go.drugbank.com/drugs/DB11934InvestigationalEpelsiban has been investigated for the treatment of Premature Ejaculation.
Categories: Heterocyclic Compounds, 1-Ring