Guadecitabine

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DB11918InvestigationalSmall molecule

Guadecitabine is under investigation for the treatment of Previously Treated Metastatic Colorectal Cancer.

Formula / weight: C₁₈H₂₄N₉O₁₀P · 557.417 g/mol (avg)
Code names: SGI-110

Resolves to

Compound

UNII2KT4YN1DP7CAS929901-49-5ChEMBLCHEMBL3544916PubChem71587872

Structure

InChIKeyGUWXKKAWLCENJA-WGWHJZDNSA-NSMILESNC1=NC(=O)C2=C(N1)N(C=N2)[C@H]1C[C@H](O)[C@@H](COP(O)(=O)O[C@H]2C[C@@H](O[C@@H]2CO)N2C=NC(N)=NC2=O)O1

Targets

P26358DNMT1

What you can answer from here — as of August 30, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action

Listed above

39Drug interactionsStructured to mechanism, not free text

31Clinical trialsPhase, status and sponsor resolved per trial

1+ReferenceStructured and connected to the statements they support

Which drugs share a target with Guadecitabine, and which of those have an active Phase 3 trial?

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