Rociletinib

DB11907InvestigationalSmall molecule

Rociletinib has been used in trials studying the treatment and prevention of Nonsmall Cell Lung Cancer, Non-small Cell Lung Cancer, and Locally Advanced or Metastatic Non-small Cell Lung Cancer.

Chemical structure of Rociletinib
Mechanism
Curator reviewed
Formula / weight
C27H28F3N7O3 · 555.562 g/mol (avg)
Code names
AVL-301 · CNX-419 · CO-1686 · CS-1631

Resolves to

Compound
UNII72AH61702GCAS1374640-70-6ChEMBLCHEMBL3545308PubChem57335384
Clinical / RWD
ATCL01EB05
Structure
InChIKeyHUFOZJXAKZVRNJ-UHFFFAOYSA-NSMILESCOC1=CC(=CC=C1NC1=NC=C(C(NC2=CC=CC(NC(=O)C=C)=C2)=N1)C(F)(F)F)N1CCN(CC1)C(C)=O
Targets
P00533EGFR

What you can answer from here — as of June 15, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action
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39Drug interactionsStructured to mechanism, not free text
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6Clinical trialsPhase, status and sponsor resolved per trial
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1ATC codeIncluding every combination product, plus 7 drug categories
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5+ReferencesStructured and connected to the statements they support
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Which drugs share a target with Rociletinib, and which of those have an active Phase 3 trial?

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