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Cisatracurium
go.drugbank.com/drugs/DB00565ApprovedInvestigationalCisatracurium acts on cholinergic receptors, blocking neuromuscular transmission. This action is antagonized by acetylcholinesterase inhibitors such as neostigmine. … [A243416,A253592] Cisatracurium is an R-cis-R-cis isomer of [atracurium] and has approximately 3 times its neuromuscular blocking potency.
Products: Nimbex 10mg/ml, KABICURIUM® 10MG/5MLPaliperidone
go.drugbank.com/drugs/DB01267ApprovedInvestigationalThe mechanism of action is unknown but it is likely to act via a similar pathway to risperidone. … Paliperidone was approved by the FDA for treatment of schizophrenia on December 20, 2006.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeProducts: INVEGA SUSTENNA® SUSPENSIÓN DE LIBERACIÓN PROLONGADA DE 25MG, INVEGA Sustenna Prolonged Release Suspension for IM Injection 100mg/1.0mlNo primary neurological disease, idiopathic decreased mental activity
go.drugbank.com/conditions/DBCOND0141360Synonyms: No primary neurological disease, idiopathic decreased mental activity, No primary neurologial disease, idiopathic decreased mental activityTocilizumab
go.drugbank.com/drugs/DB06273ApprovedInvestigational[L40164] Subsequently, it was granted approval by Health Canada and the FDA in October [L43697] and December 2022, respectively. … [L12789] It was later approved by Health Canada on 30 April 2010.
Categories: Amino Acids, Peptides, and Proteins, Antineoplastic and Immunomodulating AgentsProducts: Actemra Concentrate for Solution for Infusion 20mg/ml, ACTEMRA® CONCENTRADO PARA INFUSION 200 MG/10MLLetrozole
go.drugbank.com/drugs/DB01006ApprovedInvestigational[A190543,A1559,L11623,L11626] It is a third generation aromatase inhibitor like [exemestane] and [anastrozole], meaning it does not significantly affect cortisol, aldosterone, and thyroxine. … Letrozole, or CGS 20267, is an oral non-steroidal type II aromatase inhibitor first described in the literature in 1990.
Mixtures: Kisqali Femara Co-pack, Kisqali Femara Co-packCategories: Antineoplastic and Immunomodulating Agents, Hormone Antagonists and Related AgentsDosulepin
go.drugbank.com/drugs/DB09167ApprovedInvestigationalIt is not FDA-approved due to low therpeutic index and significant toxicity in overdose. … Dosulepsin is a thio derivative of [DB00321] with a similar efficacy to that of [DB00321], and also exhibits anticholinergic, antihistamine and central sedative properties [L882].
Categories: Non-Selective Monoamine Reuptake Inhibitors, Serotonergic Drugs Shown to Increase Risk of Serotonin SyndromeSynonyms: (3E)-3-dibenzo[b,e]thiepin-11(6H)-ylidene-N,N-dimethylpropan-1-amineLevofloxacin
go.drugbank.com/drugs/DB01137ApprovedInvestigational[A31453,A190756] Levofloxacin was first approved by the FDA in 1996, and was approved in Canada and several South American countries soon after.[A190663] … [A190663] It reportedly carries 8 to 128-fold more activity against both gram-negative and gram-positive bacteria compared to R-(+)-ofloxacin[A190663] and remains stereochemically stable following administration
Categories: Alimentary Tract and Metabolism, levofloxacin and ornidazoleProducts: NEO LEVO, Levaquin 25mg/mlNitazoxanide
go.drugbank.com/drugs/DB00507ApprovedInvestigationalVet approvedNitazoxanide is a first-line, standard treatment for illness caused by C. parvum or G. lamblia infection in healthy (not immunosuppressed) adults and children and may also be considered in the treatment … of illnesses caused by other protozoa or helminths [A31976].
Categories: ofloxacin and nitazoxanide, Antiparasitic Products, Insecticides and RepellentsProducts: NODIK® 100MG/5MLSUSPENSION, NIZOX® 100MG / 5ML SUSPENSIÓNGentamicin
go.drugbank.com/drugs/DB00798ApprovedInvestigationalVet approved[A234364] This synergistic activity is not only important for the treatment of complex infections, but can also contribute to dose optimization and reduced adverse effects. … [A234339,A234354] Gentamicin is effective against both gram-positive and gram-negative organisms but is particularly useful for the treatment of severe gram-negative infections including those caused by
Mixtures: Garasone Ophthalmic and Otic Solution, QUADRIDERM NFCategories: Ophthalmological and Otological PreparationsTrimetrexate
go.drugbank.com/drugs/DB01157ApprovedIt is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against pneumocystis pneumonia in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
Categories: Antiparasitic Products, Insecticides and RepellentsProducts: Neutrexin Pws IV 25mg/vial