Search
Sulfamoxole
go.drugbank.com/drugs/DB08798ExperimentalSulfamoxole is an antibacterial in the sulfonamide class.
Categories: Cytochrome P-450 CYP2C9 Inhibitors, Cytochrome P-450 Enzyme InhibitorsSynonyms: N(sup 1)-(4,5-Dimethyl-2-oxazolyl)sulfanilamide, 4-Amino-N-(4,5-dimethyl-2-oxazolyl)benzenesulfonamideTofisopam
go.drugbank.com/drugs/DB08811InvestigationalTofisopam (marketed under brand names Emandaxin and Grandaxin) is a 2,3-benzodiazepine drug which is a benzodiazepine derivative. … The D-enantiomer ([dextofisopam]) is currently in phase II trials in the U.S. for the treatment of irritable bowel syndrome.
Categories: Heterocyclic Compounds, 2-Ring, Cytochrome P-450 CYP3A InhibitorsNadroparin
go.drugbank.com/drugs/DB08813ApprovedInvestigationalWithdrawnThe amplification of the fibrin clotting cascade is stopped once factors Xa and IIa are inactivated. It is derived from porcine sources and has a mean molecular size of 5000 daltons. … Nadroparin is a low molecular weight heparin (LMWH) which, when bound to antithrombin III (ATIII), accelerates the inactivation of factor II and factor Xa.
Products: FRAXODI 19000 IU AXA/1 ML SC ENJEKTABL SOLUSYON 2 ENJEKTOR, FRAXODI 11400 IU AXA/0,6 ML SC ENJEKTABL SOLUSYON 2 ENJEKTORVismodegib
go.drugbank.com/drugs/DB08828ApprovedInvestigationalAfterwards, it is silenced in all cells and tissues, except for hair, skin and stem cells. … Vismodegib is an orally active small molecule that inhibits the hedgehog signaling pathway by binding to and inhibiting the transmembrane protein smoothened homologue (SMO).
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesSynonyms: 2-chloro-N-(4-chloro-3-pyridin-2-yl)phenyl)-4-(methylsulfonyl)benzamide, Benzamide, 2-chloro-N-(4-chloro-3-(2-pyridinyl)phenyl)-4-(methylsulfonyl)-Spaglumic acid
go.drugbank.com/drugs/DB08835InvestigationalSpaglumic acid is the β-aspartyl isoform of N-Acetyl-l-aspartylglutamate (isospaglumic Acid is N-(N-Acetyl-l-α-aspartyl)-l-glutamic acid). … In eye drops, spaglumic acid is either a magnesium or sodium salt of N-Acetyl-l-aspartylglutamate. Spaglumic acid is a mast cell stabilizer.
Synonyms: N-Acetyl-L-β-aspartyl-L-glutamic acidProducts: NAAXIA EYEDROPS 4.9 g/100 mlDADLE
go.drugbank.com/drugs/DB08856ExperimentalA delta-selective opioid (ANALGESICS, OPIOID). It can cause transient depression of mean arterial blood pressure and heart rate.
Synonyms: H-Tyr-D-Ala-Gly-Phe-D-Leu, L-Tyrosyl-D-alanylglycyl-L-phenylalanyl-D-leucineBoceprevir
go.drugbank.com/drugs/DB08873ApprovedWithdrawnBoceprevir is an inhibitor of NS3/4A, a serine protease enzyme, encoded by HCV genotypes 1 and 4 [synthesis]. … Boceprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV).
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesProducts: VICTRELIS ® CAPSULAS 200 MG (MOLECULA PROTEGIDA)Asparaginase Erwinia chrysanthemi
go.drugbank.com/drugs/DB08886ApprovedInvestigationalAsparaginase _Erwinia chrysanthemi_ is an asparaginase-specific enzyme derived from _Erwinia_ _chrysanthemi_ used as an anticancer agent. … [L1448] L-asparaginase was first identified in 1963,[A236344] and there are different formulations of L-asparaginase, including [Asparaginase Escherichia coli] and a pegylated form of this enzyme, [Pegaspargase
Synonyms: Erwinia L-asparaginase, L-asparaginase (Erwinia)Carfilzomib
go.drugbank.com/drugs/DB08889ApprovedInvestigationalCarfilzomib is an injectable antineoplastic agent (IV only). Chemically, it is a modified tetrapeptidyl epoxide and an analog of epoxomicin. It is also a selective proteasome inhibitor. … FDA approved carfilzomib in July 2012 for the treatment of adults with relapsed or refractory multiple myeloma as monotherapy or combination therapy.[L39392]
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, P-glycoprotein inhibitorsProducts: KYPROLIS®, KARFIB®Teduglutide
go.drugbank.com/drugs/DB08900ApprovedInvestigationalTeduglutide is a glucagon-like peptide-2 (GLP-2) analogue. It is made up of 33 amino acids and is manufactured using a strain of Escherichia coli modified by recombinant DNA technology. … The significance of this substitution is that teduglutide is longer acting than endogenous GLP-2 as it is more resistant to proteolysis from dipeptidyl peptidase-4. FDA approved on December 21, 2012.
Categories: Glucagon-like Peptide-2 (GLP-2) Agonists, GLP-2 AnalogSynonyms: Gly(2)-GLP-2, (Gly2)GLP-2