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Ombitasvir
go.drugbank.com/drugs/DB09296ApprovedInvestigationalOmbitasvir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). … Ombutasvir is also available as a fixed-dose combination product with [DB09297] and [DB00503] as the FDA- and Health Canada-approved product Technivie.
Categories: P-glycoprotein substrates, Treatments for Hepatitis CSynonyms: dimethyl ([(2S,5S)-1-(4-tert-butylphenyl)pyrrolidine-2,5-diyl]bis{(4,1-phenylene)carbamoyl(2S)pyrrolidine-2,1-diyl[(2S)-3-methyl-1-oxobutane-1,2-diyl]})biscarbamateParitaprevir
go.drugbank.com/drugs/DB09297ApprovedInvestigationalAs a newer generation and directly acting HCV antiviral, paritaprevir products have better Sustained Virological Response (SVR) rates, higher barriers to resistance, fewer side effects, and a reduced pill … Paritaprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV).
Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesSynonyms: (2R,6S,12Z,13aR,14aR,16aS)-N-(cyclopropanesulfonyl)-6-[(5-methylpyrazine-2-carbonyl)amino]-5,16-dioxo-2-[(phenanthridin-6-yl)oxy]-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrocyclopropa[e]pyrrolo, [1,2-a][1,4]diazacyclopentadecine-14a(5H)-carboxamideAptazapine
go.drugbank.com/drugs/DB09305ExperimentalAptazapine (CGS-7525A) was a tetracyclic antidepressant developed in the 1980s. Aptazapine had noradrenergic and specific serotonergic activity. … It antagonised α2 adrenergic receptors approximately 10 times more effectively than mianserin, antagonised 5-HT2 receptors, agonised H1 receptors, and did not affect reuptake of serotonin or norepinephrine
Categories: Heterocyclic Compounds, 2-RingSolithromycin
go.drugbank.com/drugs/DB09308InvestigationalSolithromycin is a ketolide antibiotic undergoing clinical development for the treatment of community-acquired pneumonia (CAP) and other infections.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesAntilymphocyte immunoglobulin (horse)
go.drugbank.com/drugs/DB09312ApprovedInvestigationalThe result is polyclonal IgG that is then purified from the horse's serum to produce a usable drug product that can be used for immunosuppression. … Induction of T cell apoptosis and resulting T-cell lymphopenia found in vivo is credited for its therapeutic effect in these conditions.
Categories: Immunoglobulin G, Increased T Lymphocyte DestructionSynonyms: e-ATG, h-ATGTegafur-uracil
go.drugbank.com/drugs/DB09327ApprovedTegafur-uracil is an anti-tumor compound containing tegafur (1-(2-tetrahydrofuryl)-5-fluorouracil) and uracil in a molar ratio of 1:4. … It was developed as an anti-cancer therapy by Taiho Pharmaceutical Co Ltd.[A32073] It is approved in different countries but it is not yet approved by the FDA, Health Canada or EMA.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 SubstratesVayarin
go.drugbank.com/drugs/DB09328ApprovedVayarin is a novel therapy for ADHD that appears to be effective in several studies [L1501, L1502, L1503]. … A slow response time of 12 weeks is an impediment to successful management of ADHD as only 41.6% of subjects prescribed Vayarin remained compliant for the duration of the study.
Categories: Cytochrome P-450 CYP2E1 Inhibitors, Cytochrome P-450 Enzyme InhibitorsSeractide acetate
go.drugbank.com/drugs/DB09334ApprovedSeractide acetate is the acetate salt of full length human corticotropin.
Invert sugar
go.drugbank.com/drugs/DB09344Experimental[A32124] Invert sugar is FDA approved since 1988 as a safe substance (GRAS). … Invert sugar is obtained from sugar cane when this is treated with dilute acid or with the invertase enzyme. It is formed by an equal amount of glucose and fructose.
Categories: Compounds used in a research, industrial, or household settingGastric intrinsic factor
go.drugbank.com/drugs/DB09349ApprovedIntrinsic factor (IF), also known as gastric intrinsic factor (GIF), is a glycoprotein produced by the parietal cells of the stomach that is necessary for the absorption of vitamin B12 (cobalamin) later … Intrinsic factor is not currently available in any FDA or Health Canada approved products.