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Zileuton
go.drugbank.com/drugs/DB00744ApprovedWithdrawnBoth the R(+) and S(-) enantiomers are pharmacologically active as 5-lipoxygenase inhibitors in in vitro systems. The immediate release tablet of Zileuton has been withdrawn from the US market. … Zileuton relieves such symptoms through its selective inhibition of 5-lipoxygenase, the enzyme that catalyzes the formation of leukotrienes from arachidonic acid.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 InhibitorsSynonyms: (±)-1-(1-Benzo[b]thien-2-ylethyl)-1-hydroxyurea, N-(1-Benzo(b)thien-2-ylethyl)-N-hydroxyureaTretinoin
go.drugbank.com/drugs/DB00755ApprovedInvestigationalNutraceuticalTretinoin, also known as all-trans-retinoic acid (ATRA), is a naturally occurring derivative of [vitamin A] (retinol). … [A257689] In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L.
Synonyms: (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid, 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexene-1-yl)-2,4,6,8-nonatetraenoic acid (ECL)International brands: Stieva-AHexachlorophene
go.drugbank.com/drugs/DB00756ApprovedWithdrawnA chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms.
Synonyms: 2,2'-dihydroxy-3,5,6,3',5',6'-hexachlorodiphenylmethane, bis(2-hydroxy-3,5,6-trichlorophenyl)methaneInternational brands: E-Z scrub, Staphene OIrinotecan
go.drugbank.com/drugs/DB00762ApprovedInvestigational[L50186] The active metabolite SN-38 is also a potent inhibitor of DNA topoisomerase I. … Irinotecan is a topoisomerase inhibitor used for chemotherapy. It is a water-soluble analogue of [camptothecin], which is extracted from the Chinese tree _Camptotheca acuminate_.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexSynonyms: (S)-4,11-diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl 4-(2-(5-(3-(2,4-dihydroxy-5-isopropylphenyl)-5-hydroxy-4H-1,2,4-triazol-4-yl)-1H-indol-1-yl, )ethyl)piperidine-1-carboxylateMethimazole
go.drugbank.com/drugs/DB00763ApprovedInvestigationalMethimazole is a thionamide antithyroid agent that inhibits the synthesis of thyroid hormones. … [L8336,L8339] On a weight basis, methimazole is 10 times more potent than the other major antithyroid thionamide used in North America, [propylthiouracil],[L8339] and is the active metabolite of the
Categories: Cytochrome P-450 CYP1A2 Inhibitors, Cytochrome P-450 CYP2A6 InhibitorsSynonyms: 1-Methylimidazole-2(3H)-thioneMometasone
go.drugbank.com/drugs/DB00764ApprovedInvestigationalMometasone is a corticosteroid not currently used in medical products. [Mometasone furoate] however, is still in use.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InducersProducts: MOMECUTAN SALBE 1 MG/G, MONOVO 1MG/G EMU Z ANW HAUMetyrosine
go.drugbank.com/drugs/DB00765ApprovedInvestigationalAn inhibitor of the enzyme tyrosine 3-monooxygenase, and consequently of the synthesis of catecholamines.
Synonyms: α-methyl-L-p-tyrosine, (–)-α-methyl-L-tyrosineEtoposide
go.drugbank.com/drugs/DB00773ApprovedInvestigationalA semisynthetic derivative of podophyllotoxin that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. … Etoposide acts primarily in the G2 and S phases of the cell cycle.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic IndexSynonyms: 9-((4,6-O-Ethylidine-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-d)-1,3-dioxol-6(5aH)-one, 4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-beta-D-glucopyranoside)Oxcarbazepine
go.drugbank.com/drugs/DB00776ApprovedInvestigational- a pro-drug of the more active (S)-enantiomer is also marketed as a separate anti-epileptic under the name [eslicarbazepine]. … [L8627,L8630,L8633] It is a structural derivative of [carbamazepine][A186101] and exerts a majority of its activity via a pharmacologically active metabolite, MHD, which exists as a racemate in the blood
Categories: P-glycoprotein inducers, P-glycoprotein substratesSynonyms: 10,11-Dihydro-10-oxo-5H-dibenz(b,f)azepine-5-carboxamideEstradiol
go.drugbank.com/drugs/DB00783ApprovedInvestigationalVet approvedEstradiol is a naturally occurring hormone circulating endogenously in females. … Because it has a low oral bioavailability on its own, estradiol is commonly formulated with an ester side-chain.
Mixtures: FEMOSTON CONTI 1/5, FEMOSTON CONTI 1/5 TABLETCategories: P-glycoprotein substrates, Cytochrome P-450 Substrates