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Displaying results 841 - 850 of 10000 in total
  1. Drug

    Sitagliptin

    go.drugbank.com/drugs/DB01261
    ApprovedInvestigational

    Sitagliptin is an oral dipeptidyl peptidase-4 (DPP-4) inhibitor used in conjunction with diet and exercise to improve glycemic control in patients with type 2 diabetes mellitus[FDA label,A2260,A2255,A2256 … The effect of this medication leads to glucose dependent increases in insulin and decreases in glucagon to improve control of blood sugar[FDA label,A2255].

    Mixtures: Nb-sitagliptin-metformin, Nb-sitagliptin-metforminCategories: DPP-IV Inhibitors, Drugs Used in Diabetes
  2. Target

    Aminoglycoside 3'-phosphotransferase

    go.drugbank.com/bio_entities/BE0003548
    EnzymeEscherichia coli

    Resistance to kanamycin and structurally-related aminoglycosides, including amikacin.

    Synonyms: APH(3')I, APH(3')-I
  3. Drug

    Paclitaxel

    go.drugbank.com/drugs/DB01229
    ApprovedInvestigationalVet approved

    It is available as an intravenous solution for injection and the newer formulation contains albumin-bound paclitaxel marketed under the brand name Abraxane. … Paclitaxel is a chemotherapeutic agent marketed under the brand name Taxol among others.

    Synonyms: 5beta,20-Epoxy-1,2-alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine, Taxol ACategories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index
  4. Indication

    Pseudohypoparathyroidism

    go.drugbank.com/conditions/DBCOND0008696
    Drugs: Dihydrotachysterol
    Synonyms: Pseudohypoparathyroidism type I A (disorder)
  5. Target

    Gentamicin 3-N-acetyltransferase

    go.drugbank.com/bio_entities/BE0001953
    TargetPseudomonas aeruginosa

    Responsible for gentamicin resistance and has a limited substrate range.

    Synonyms: AAC(3)-I, Gentamicin acetyltransferase I
  6. Drug

    Ondansetron

    go.drugbank.com/drugs/DB00904
    ApprovedInvestigationalWithdrawn

    Having been developed in the 1980s by GlaxoSmithKline and approved by the US FDA since January 1991, ondansetron has demonstrated a long history of use and efficacy. … It is effective in the treatment of nausea and vomiting caused by cytotoxic chemotherapy drugs, including cisplatin, and has reported anxiolytic and neuroleptic properties.

    Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, P-glycoprotein substratesProducts: Nu-ondansetron, NODANTON-I
  7. Drug

    Lisinopril

    go.drugbank.com/drugs/DB00722
    ApprovedInvestigational

    [A184853] It functions by inhibition of angiotensin converting enzyme as well as the renin angiotensin aldosterone system. … Lisinopril is an angiotensin converting enzyme inhibitor (ACEI) used to treat hypertension, heart failure, and myocardial infarction.

    Mixtures: Nu-lisinopril/hctz, Nu-lisinopril/hctzCategories: Compounds used in a research, industrial, or household setting, Agents Acting on the Renin-Angiotensin System
  8. Target

    GTP cyclohydrolase 1

    go.drugbank.com/bio_entities/BE0001814
    TargetShigella flexneri

    Synonyms: GTP-CH-I, GTP cyclohydrolase I
  9. Target

    Carbamoyl-phosphate synthase [ammonia], mitochondrial

    go.drugbank.com/bio_entities/BE0004671
    TargetEnzymeHumans

    Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell

    Synonyms: CPSase I, Carbamoyl-phosphate synthetase I
  10. Target

    Deoxyribonuclease-1

    go.drugbank.com/bio_entities/BE0012829
    TargetHumans

    Serum endocuclease secreted into body fluids by a wide variety of exocrine and endocrine organs (PubMed:11241278, PubMed:2251263, PubMed:2277032). Expressed by non-hematopoietic tissues and preferentially cleaves protein-free DNA (By sim...

    Synonyms: DNase I, Deoxyribonuclease IFunction: deoxyribonuclease I activity