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Cladribine
go.drugbank.com/drugs/DB00242ApprovedInvestigational[A263733] In 2017 in Europe and in 2019 in the United States, cladribine was also approved for the treatment multiple sclerosis.[A263718] … [A350] Cladribine was first approved in the United States in 1993 [A263713] initially as a treatment for a number of hematological malignancies; currently, it is approved for the treatment of hairy cell
Categories: 2-Chloroadenosine, Heterocyclic Compounds, 2-RingSynonyms: 2-Chloro-2'-deoxyadenosine, 2-chloro-2′-deoxy-adenosineLomitapide
go.drugbank.com/drugs/DB08827ApprovedLomitapide, marketed under the brand names Juxtapid (USA) and Lojuxta (EU), is a first-in-class, small-molecule inhibitor of microsomal triglyceride transfer protein (MTP). … [A7367] Lomitapide was first approved by the FDA in December 2012 and the EMA in July 2013 as an adjunct to a low-fat diet and other lipid-lowering treatments.[A275444, A275446]
Categories: Heterocyclic Compounds, 2-RingSynonyms: 9H-FLUORENE-9-CARBOXAMIDE, N-(2,2,2-TRIFLUOROETHYL)-9-(4-(4-(((4'-(TRIFLUOROMETHYL)(1,1'-BIPHENYL)-2-YL)CARBONYL)AMINO)-1-PIPERIDINYL)BUTYL)-, N-(2,2,2-TRIFLUOROETHYL)-9-(4-(4-(((4'-(TRIFLUOROMETHYL)BIPHENYL-2-YL)CARBONYL)AMINO)PIPERIDIN-1-YL)BUTYL)-9H-FLUORENE-9-CARBOXAMIDETretinoin
go.drugbank.com/drugs/DB00755ApprovedInvestigationalNutraceutical[A257689] In human circulation, tretinoin is normally found at very low concentrations, approximately 4 to 14 nmol/L. … [A257474] It is an oxidation product in the physiological pathway of vitamin A metabolism.
Mixtures: Acnatac 10 mg/g + 0,25 mg/g Gel, CLİNDATRE 12 MG/G + 0,25 MG/G JEL, 30 GRAMCategories: Retinoids for Topical Use in AcneIoversol
go.drugbank.com/drugs/DB09134ApprovedInvestigational[L41780] Ioversol was approved by the FDA in 1989 and is currently indicated for computed tomographic (CT) imaging and contrast enhancement in peripheral arteriography, coronary arteriography, and left … Ioversol is a non-ionic compound with a tri-iodinated benzene ring used as a contrast dye in diagnostic procedures to visualize different types of organs and tissues.
Categories: Compounds used in a research, industrial, or household settingSynonyms: N,N'-Bis (2,3-dihydroxypropyl)-5-[N-(2-hydroxyethyl) -glycolamido] -2,4,6-triiodoisophthalamideFlucloxacillin
go.drugbank.com/drugs/DB00301ApprovedInvestigationalWithdrawnAntibiotic analog of cloxacillin.
Categories: Heterocyclic Compounds, 2-RingSynonyms: (2S,5R,6R)-6-({[3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3-(2-Chloro-6-fluorophenyl)-5-methyl-4-isoxazolylpenicillinMethenamine
go.drugbank.com/drugs/DB06799ApprovedInvestigationalVet approvedIn salt form it is used for the treatment of urinary tract infection (Example: methenamine hippurate which is the hippuric acid salt of methenamine).
Mixtures: PURINOL 250 mg+615 mg/5 g EFERVESAN 70 GR, PURINOL 250 mg+615 mg/5 g EFERVESAN 70 GRProducts: URON 500 MG TABLET, 21 ADET, NETURONE GRANUL LIBA, 70 GClorazepic acid
go.drugbank.com/drugs/DB00628ApprovedIllicitIn September 2020, a black box warning describing these risks was included on the product label of benzodiazepines as per FDA regulation. … [L44798] Clorazepate and its active metabolite, nordiazepam, are present in breast milk.[A958,L44788]
Categories: Heterocyclic Compounds, 2-RingSynonyms: 7-chloro-2,3-dihydro-2,2-dihydroxy-5-phenyl-1H-1,4-benzodiazepine-3-carboxylic acidTacrolimus
go.drugbank.com/drugs/DB00864ApprovedInvestigationalThis FKBP12-FK506 complex inhibits calcineurin which inhibits T-lymphocyte signal transduction and IL-2 transcription. … It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex.
Mixtures: Hyaluronic Acid Sodium Salt 1% / Tacrolimus 0.1% / Urea 20%, Hyaluronic Acid Sodium Salt 1% / Niacinamide 4% / Tacrolimus 0.1%Products: TACROLIMUS EG, PROGRAF 5 MG/ML KONSANTRE IV INFUZYON ICIN SOLUSYON ICEREN AMPUL, 10 ADETNaloxone
go.drugbank.com/drugs/DB01183ApprovedInvestigationalVet approved[L33714,L33719] Naloxone was granted FDA approval on 13 April 1971.[L33709] … [L33734] Kits commonly include the supplies necessary to treat an overdose in a non-medical setting such as alcohol swabs, syringes, a rescue breathing mask, and instructions for use.
Mixtures: Targin 20 mg/10 mg Retardtabletten, Oxylanox 20 mg/10 mg-RetardtablettenSynonyms: 1-N-Allyl-14-hydroxynordihydromorphinone, 17-allyl-3,14-dihydroxy-4,5α-epoxymorphinan-6-oneCarvedilol
go.drugbank.com/drugs/DB01136ApprovedInvestigational[A182306] Carvedilol was granted FDA approval on 14 September 1995.[L7889] … [L7889,L7892] The dual action of carvedilol is advantageous in combination therapies as moderate doses of 2 drugs have a decreased incidence of adverse effects compared to high dose monotherapy in the
Mixtures: Co-Dilatrend 25 mg/12,5 mg - Filmtabletten, CARIVALAN 25/5Categories: Heterocyclic Compounds, 2-Ring, Adrenergic alpha-1 Receptor Antagonists