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Minocycline
go.drugbank.com/drugs/DB01017ApprovedInvestigational[A190723] Like other semisynthetic tetracyclines, minocycline has modifications to carbons 7-9 on the D ring to generate higher efficacy than previous tetracyclines. … [A190681] It is a second generation tetracycline antibiotic that is active against gram-negative and gram-positive bacteria.
Synonyms: 7-Dimethylamino-6-demethyl-6-deoxytetracycline, (4S,4aS,5aR,12aS)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamideProducts: PERIOCLINE PERIODONTAL OINTMENT 2% W/W, XELTETRA-MMethoxyflurane
go.drugbank.com/drugs/DB01028ApprovedInvestigationalVet approvedWithdrawnIf so employed, it should be administered with nitrous oxide to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesProducts: PENTHROX®, Penthrop 99,9%, 3 ml Flüssigkeit zur Herstellung eines Dampfs zur InhalationTopotecan
go.drugbank.com/drugs/DB01030ApprovedInvestigationalIt works by inhibiting DNA topoisomerases, type I.
Categories: MATE 1 Substrates with a Narrow Therapeutic Index, MATE 2 Substrates with a Narrow Therapeutic IndexSynonyms: 9-[(dimethylamino)methyl]-10-hydroxy-(4S)-camptothecinProbenecid
go.drugbank.com/drugs/DB01032ApprovedInvestigationalThe prototypical uricosuric agent. It inhibits the renal excretion of organic anions and reduces tubular reabsorption of urate. Probenecid has also been used to treat patients with renal impairment, and, because it reduces the renal tubu...
Synonyms: 4-(N,N-Dipropylsulfamoyl)benzoesäure, 4-(Di-n-propylsulfamoyl)benzoesäureCategories: Cytochrome P-450 CYP2C8 Inducers, Cytochrome P-450 CYP3A InducersProcainamide
go.drugbank.com/drugs/DB01035ApprovedA derivative of procaine with less CNS action.
Categories: MATE 1 Substrates with a Narrow Therapeutic Index, MATE 2 Substrates with a Narrow Therapeutic IndexSynonyms: p-Amino-N-(2-diethylaminoethyl)benzamide, p-Aminobenzoic diethylaminoethylamideBenzylpenicillin
go.drugbank.com/drugs/DB01053ApprovedInvestigationalVet approvedAminoglycosides may be added for synergy against group B streptococcus (*S. agalactiae*), *S. viridans*, and *Enterococcus faecalis*. … Natural penicillins are considered the drugs of choice for several infections caused by susceptible gram positive aerobic organisms, such as *Streptococcus pneumoniae*, groups A, B, C and G streptococci
Mixtures: Bicillin C-R 900/300, Bicillin A-P Injection PwsCategories: Penicillin G, Heterocyclic Compounds, 1-RingMimosine
go.drugbank.com/drugs/DB01055ExperimentalMimosine is an antineoplastic alanine-substituted pyridine derivative isolated from Leucena glauca.
Synonyms: (S)-2-amino-3-(3-hydroxy-4-oxo-4H-pyridin-1-yl)propanoate, (L)-MimosineCategories: Heterocyclic Compounds, 1-RingTocainide
go.drugbank.com/drugs/DB01056ApprovedWithdrawnAn antiarrhythmic agent which exerts a potential- and frequency-dependent block of sodium channels.
Categories: Antiarrhythmics, Class I, Cytochrome P-450 SubstratesSynonyms: 2-Amino-2',6'-propionoxylidide, 2-amino-N-(2,6-dimethylphenyl)propanamidePraziquantel
go.drugbank.com/drugs/DB01058ApprovedInvestigationalVet approvedPraziquantel is a pyrazino-isoquinolein derivative from the thioxantonic group used as a broad anthelmintic spectrum. … Specifically, it is known as a treatment of trematodes and cestodes infections such as schistosomiasis, taeniasis, and cysticercosis.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingProducts: CISTICID ® 600MGAmoxicillin
go.drugbank.com/drugs/DB01060ApprovedInvestigationalVet approvedAmoxicillin, or BRL-2333, is a penicillin G derivative first described in the literature in 1972.
Mixtures: SUMIVULIN ® 1.2 G (1 G / 0.2 G), IPICLAV® 1 GCategories: Penicillin G, Heterocyclic Compounds, 1-Ring