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Fondaparinux
go.drugbank.com/drugs/DB00569ApprovedInvestigationalFondaparinux (Arixtra) is a synthetic anticoagulant agent consisting of five monomeric sugar units and a O-methyl group at the reducing end of the molecule. … Once bound to heparin or HS, the anticoagulant activity of ATIII is potentiated by 1000-fold. Fondaparinux potentiates the neutralizing action of ATIII on activated Factor X 300-fold.
Products: ARIXTRA ® 10MG /0.8 ML, ARIXTRA ® 7.5 MG /0.6 MLVinblastine
go.drugbank.com/drugs/DB00570ApprovedInvestigationalAntitumor alkaloid isolated from Vinca rosea. (Merck, 11th ed.)
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexProducts: VINBLASTINA10 MG X 1 FCO., VINKO 1 MG/ML IV INFÜZYON ICIN COZELTİ ICEREN FLAKON, 1 ADETCarbenicillin
go.drugbank.com/drugs/DB00578ApprovedIt is susceptible to gastric juice and penicillinase and may damage platelet function.
Categories: Penicillin G, Heterocyclic Compounds, 2-RingSynonyms: N-(2-carboxy-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)hept-6-yl)-2-phenylmalonamic acid, (2S,5R,6R)-6-{[carboxy(phenyl)acetyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acidCinalukast
go.drugbank.com/drugs/DB00587ExperimentalUsed in the treatment of asthma, cinalukast selectively antagonizes leukotriene D4 (LTD4) at the cysteinyl leukotriene receptor, CysLT1, in the human airway. Cinalukast inhibits the actions of LTD4 at the CysLT1 receptor, preventing airw...
Synonyms: 3'-((E)-2-(4-cyclobutyl-2-thiazolyl)vinyl)-2,2-diethylsuccinanilic acidCategories: Heterocyclic Compounds, 1-RingMonobenzone
go.drugbank.com/drugs/DB00600ApprovedWithdrawnMonobenzone occurs as a white, almost tasteless crystalline powder, soluble in alcohol and practically insoluble in water. … Monobenzone is the monobenzyl ether of hydroquinone used medically for depigmentation.
Synonyms: 4-(Benzyloxy)phenol, 4-BenzyloxyphenolMedroxyprogesterone acetate
go.drugbank.com/drugs/DB00603ApprovedInvestigationalMedroxyprogesterone acetate (MPA) is a [progesterone] derivative that is more resistant to metabolism for improved pharmacokinetic properties. … endometrial hyperplasia, abnormal uterine bleeding, osteoporosis, vasomotor symptoms in menopause, vulvar and vaginal atrophy, prevent pregnancy, manage pain in endometriosis, prevent pregnancy, and is
Mixtures: DIVICONT TABLETAS 1 MG/5 MG, FEMELIN®Categories: Pregnen (4) Derivatives, P-glycoprotein inhibitorsCisapride
go.drugbank.com/drugs/DB00604ApprovedWithdrawnThe FDA issued a warning letter regarding this risk to health care professionals and patients.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-RingProducts: GASTRON 1 MG/1 ML SÜSPANSİYON, 200 ML, GUARPOSID - 5Cyclothiazide
go.drugbank.com/drugs/DB00606ApprovedCyclothiazide is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. … As a diuretic, cyclothiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water.
Categories: Heterocyclic Compounds, 2-RingSynonyms: 6-chloro-3-(2-norbornen-5-yl)-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide, 6-chloro-3,4-dihydro-3-(2-norbornen-5-yl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxideNafcillin
go.drugbank.com/drugs/DB00607ApprovedInvestigationalA semi-synthetic antibiotic related to penicillin, Naficillin is a narrow-spectrum beta-lactam antibiotic drug. … It may be used as a first-line therapy in Methicillin-Sensitive *Staphylococcus aureus* infections [A20360].
Categories: Cytochrome P-450 CYP1A2 Inducers, Cytochrome P-450 CYP3A InducersSynonyms: (2S,5R,6R)-6-[(2-ethoxy-1-naphthoyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-(2-ethoxy-1-naphthamido)penicillanic acidParamethadione
go.drugbank.com/drugs/DB00617ApprovedParamethadione is an anticonvulsant in the oxazolidinedione class. It is associated with fetal trimethadione syndrome, which is also known as paramethadione syndrome.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C8 Substrates