Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function.
- Mechanism
- Curator reviewed
Free carbenicillin is the predominant pharmacologically active fraction of the salt. Carbenicillin exerts its antibacterial activity by interference with final cell wall synthesis of susceptible bacteria. Penicillins acylate the penicillin-sensitive transpeptidase C-terminal domain by opening the lactam ring. This inactivation of the enzyme prevents the formation of a cross-link of two linear peptidoglycan strands, inhibiting the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that carbenicillin interferes with an autolysin inhibitor.
- Primary indication
- For the treatment of acute and chronic infections of the upper and lower urinary tract and in asymptomatic bacteriuria due to susceptible strains of bacteria.Curator reviewed
- Formula / weight
- C17H18N2O6S · 378.4 g/mol (avg)
- Also known as
- Carboxybenzylpenicillin · CBPC
- Code names
- BRL 2064 · CP 15639-2 · NSC 111071
Resolves to
FPPNZSSZRUTDAP-UWFZAAFLSA-NSMILES[H][C@]12SC(C)(C)[C@@H](N1C(=O)[C@H]2NC(=O)C(C(O)=O)C1=CC=CC=C1)C(O)=OWhat you can answer from here — as of September 23, 2026
Which drugs share a target with Carbenicillin, and which of those have an active Phase 3 trial?
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