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Abatacept
go.drugbank.com/drugs/DB01281ApprovedInvestigationalIt is produced through recombinant DNA technology in mammalian CHO cells. The drug has activity as a selective co-stimulation modulator with inhibitory activity on T lymphocytes. … Although approved for the treatment of rheumatoid arthritis, Repligen has entered a slightly different formulation of CTLA4-Ig into clinical trials (RG2077).
Categories: Biologics for Rheumatoid Arthritis TreatmentProducts: ORENCIA Injection 125mg/ml in Prefilled SyringeLurbinectedin
go.drugbank.com/drugs/DB12674ApprovedInvestigational[A214331] On June 15, 2020, the FDA granted accelerated approval and orphan drug designation to lurbinectedin for the treatment of adult patients with metastatic SCLC who have experienced disease progression … [L14336] This accelerated approval is based on the rate and duration of therapeutic response observed in ongoing clinical trials and is contingent on the verification of these results in confirmatory trials
Products: ZEPZELCA POWDER FOR SOLUTION FOR INFUSION 4MG/VIALChoriocarcinoma
go.drugbank.com/conditions/DBCOND0017311Drugs: VincristineSynonyms: Choriocarcinoma, no International Classification of Diseases for Oncology subtype, Choriocarcinoma, no ICD-O subtypeIdursulfase
go.drugbank.com/drugs/DB01271ApprovedInvestigationalIdursulfase is a purified form of human iduronate-2-sulfatase, a lysosomal enzyme. Idursulfase is produced by recombinant DNA technology in a human cell line. … The enzyme activity of idursulfase is dependent on the post-translational modification of a specific cysteine to formylglycine.
Products: ELAPRASE SOLUTION FOR INTRAVENOUS INFUSION, Elaprase (TM) Solution for Intravenous Infusion 2mg/ mlOsteosarcoma Tumor
go.drugbank.com/conditions/DBCOND0066821Synonyms: Osteosarcoma, no International Classification of Diseases for Oncology subtype, Osteosarcoma, no ICD-O subtypeLansoprazole
go.drugbank.com/drugs/DB00448ApprovedInvestigational[A177065] It reduces gastric acid secretion by targeting gastric H,K-ATPase pumps and is thus effective at promoting healing in ulcerative diseases, and treating gastroesophageal reflux disease (GERD) … Lansoprazole marketed under the brand Prevacid, is a proton pump inhibitor (PPI) and is structurally classified as a substituted benzimidazole.
Categories: Drugs for Acid Related Disorders, Drugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord)Products: FIRST Lansoprazole Rx, Prevacid IVTremelimumab
go.drugbank.com/drugs/DB11771ApprovedInvestigationalCTLA-4 is a cell surface receptor expressed on activated T cells to act as a negative regulator for T cells. … [A253717, A253722] After receiving an EMA Committee for Medicinal Products for Human Use (CHMP) recommendation in December 2022, tremelimumab was approved for combined use with [durvalumab].[L46188]
Products: Imjudo Concentrate for Solution for Intravenous Infusion 20 mg/mLPertuzumab
go.drugbank.com/drugs/DB06366ApprovedInvestigationalIt was first approved by the FDA in 2012 for use with [docetaxel] and another HER2-targeted monoclonal antibody, [trastuzumab], in the treatment of metastatic HER2-positive breast cancer. … Its indicated conditions have since expanded to include use as both a neoadjuvant therapy and an adjuvant therapy in the treatment of HER2-positive breast cancers at high risk of recurrence.
Products: Perjeta 420 mg concentrate for solution for infusion, PERJETA CONCENTRATE FOR SOLUTION FOR INFUSION 420MG/14MLSildenafil
go.drugbank.com/drugs/DB00203ApprovedInvestigationalthe public in 1998 [A175732], continues to see millions of prescriptions written for it internationally. … before being serendipitously indicated for treating erectile dysfunction in the late 1980s [A175732].
Categories: Drugs Used in Erectile DysfunctionProducts: Sildenafil for Oral Suspension, JELIGRA 100 MG ORAL JEL IÇEREN SAŞE ,4 SAŞEErdosteine
go.drugbank.com/drugs/DB05057ApprovedInvestigationalErdosteine has been shown to be safe and well tolerated in clinical trials. … It is a _thiol_ derivative produced for the clinical management of chronic obstructive bronchitis, in addition to infective exacerbations of chronic bronchitis.
Products: ERDOSTIN 225 MG SAŞE, 20 ADET