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Displaying results 851 - 860 of 10000 in total
  1. Drug

    Halicin

    go.drugbank.com/drugs/DB15624
    Experimental

    Synonyms: 2-amino-5-[(5-nitro-2-thiazolyl)thio]-1,3,4-thiadiazoleCategories: Heterocyclic Compounds, 1-Ring
  2. Drug

    Furaltadone

    go.drugbank.com/drugs/DB16567
    Investigational

    Synonyms: (±)-5-(MORPHOLINOMETHYL)-3-((5-NITROFURFURYLIDENE)AMINO)-2-OXAZOLIDINONECategories: Heterocyclic Compounds, 1-Ring
  3. Drug

    Quizartinib

    go.drugbank.com/drugs/DB12874
    ApprovedInvestigational

    cytarabine consolidation, followed by a maintenance monotherapy resulted in a 22% reduction in the risk of death. … [L47426] FLT3-ITD mutation is present in 75% of FLT3-mutated AML, leading to constitutively active FLT3 and thus poorer overall survival and higher risk of relapse.

    Synonyms: N-(5-(1,1-Dimethylethyl)isoxazol-3-yl)-N'-(4-(7-(2-(morpholin-4-yl)ethoxy)imidazo(2,1-b)benzothiazol-2-yl)phenyl)ureaCategories: P-glycoprotein inhibitors, P-glycoprotein substrates
  4. Drug

    Mycophenolic acid

    go.drugbank.com/drugs/DB01024
    ApprovedInvestigational

    Mycophenolic acid is used in immunosuppressive regimens as part of a triple therapy that includes a calcineurin inhibitor (ciclosporin or tacrolimus) and prednisolone. … Mycophenolic acid is a potent immunosuppressant agent that inhibits _de novo_ purine biosynthesis.

    Categories: Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic IndexSynonyms: (e)-6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid
  5. Drug

    Trioxsalen

    go.drugbank.com/drugs/DB04571
    ApprovedWithdrawn

    The photoactivated form produces interstrand linkages in DNA resulting in cell apoptosis. … It is administered either topically or orally in conjunction with UV-A (the least damaging form of ultraviolet light) for phototherapy treatment of vitiligo and hand eczema.

    Synonyms: 6-hydroxy-β,2,7-trimethyl-5-benzofuranacrylic acid, δ-lactone, 2',4,8-TrimethylpsoralenCategories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-Ring
  6. Drug

    Brensocatib

    go.drugbank.com/drugs/DB15638
    Approved

    [A274348] Brensocatib is a first-in-class dipeptidyl peptidase 1 (DPP1) inhibitor that inhibits neutrophil serine proteases, addressing a key driver of this inflammation. … [A274348] Brensocatib was approved by the US FDA on August 12, 2025, for use in adults and pediatric patients with NCFB.[L53808,L53813]

    Categories: MATE 1 Inhibitors, MATE 2 InhibitorsSynonyms: (S)-N-((S)-1-Cyano-2-(4-(3-methyl-2-oxo-2,3-dihydrobenzo-(d)oxazol-5-yl)phenyl)ethyl)-1,4-oxazepane-2-carboxamide
  7. Drug

    Sulfabromomethazine

    go.drugbank.com/drugs/DB11547
    ExperimentalVet approved

    Synonyms: 5-bromosulfamethazine
  8. Drug

    Bupicomide

    go.drugbank.com/drugs/DB19556
    Experimental

    Bupicomide is a small molecule drug. Bupicomide has a monoisotopic molecular weight of 178.11 Da.

    Categories: Heterocyclic Compounds, 1-RingSynonyms: 5-butylpicolinamide
  9. Drug

    Gemcitabine

    go.drugbank.com/drugs/DB00441
    ApprovedInvestigational

    [A233135] Gemcitabine is a cytidine analog with two fluorine atoms replacing the hydroxyl on the ribose. … Gemcitabine is a nucleoside analog and a chemotherapeutic agent. It was originally investigated for its antiviral effects, but it is now used as an anticancer therapy for various cancers.

    Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, P-glycoprotein substratesSynonyms: 4-amino-1-((2R,4R,5R)-3,3-difluoro-4-hydroxy-5-(hydroxymethyl)-tetrahydrofuran-2-yl)pyrimidin-2(1H)-one, 2'-Deoxy-2',2'-difluorocytidine
  10. Drug

    2-Oxy-4-Hydroxy-5-(2-Hydrazinopyridine)Phenylalanine

    go.drugbank.com/drugs/DB01634
    Experimental

    Synonyms: 2-Oxy-4-Hydroxy-5-(2-Hydrazinopyridine)Phenylalanine