Trioxsalen is a psoralen derivative that has been used in combination with UV light to treat vitiligo, but has been discontinued by its manufacturer. Trioxsalen (trimethylpsoralen, trioxysalen or trisoralen) is a furanocoumarin and a psoralen derivative obtained from several plants, mainly Psoralea corylifolia.
- Mechanism
- Curator reviewed
After photoactivation it creates interstrand cross-links in DNA, which can cause programmed cell death.
- Primary indication
- Trioxsalen is a pigmenting photosensitizing agent used in conjunction with ultraviolet light in the treatment of vitiligo.Curator reviewed
- Formula / weight
- C14H12O3 · 228.2433 g/mol (avg)
- First approval
- Canada, 1993
- Also known as
- Trimethylpsoralen · Trioxysalen · Trisoralen
- Code names
- NSC-71047
Resolves to
Clinical / RWD
Structure
InChIKey
FMHHVULEAZTJMA-UHFFFAOYSA-NSMILESCC1=CC2=CC3=C(OC(=O)C=C3C)C(C)=C2O1What you can answer from here — as of September 13, 2026
1Protein targetEach mapped to UniProt, with action and pharmacological actionListed above
Which companies are running trials of Trioxsalen, in which indications and phases, and which of those programs are still active?
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