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Carbinoxamine
go.drugbank.com/drugs/DB00748ApprovedThe product label for carbinoxamine as an over the counter cough and cold medicine is being modified to state "do not use" in children under 4 years of age in order to prevent and reduce misuse, as many … Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor sites.
Mixtures: Coldec DS, PHILDEX 2Categories: Heterocyclic Compounds, 1-RingEthotoin
go.drugbank.com/drugs/DB00754ApprovedEthotoin is no longer commonly used. … Ethotoin is a hydantoin derivative and anticonvulsant. Ethotoin exerts an antiepileptic effect without causing general central nervous system depression.
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersSynonyms: (±)-3-ethyl-5-phenylhydantoin, 3-ethyl-5-phenylhydantoinDolasetron
go.drugbank.com/drugs/DB00757ApprovedInvestigationalDolasetron is a highly specific and selective serotonin 5-HT3 receptor antagonist. … This drug is not shown to have activity at other known serotonin receptors, and has low affinity for dopamine receptors.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingMeropenem
go.drugbank.com/drugs/DB00760ApprovedInvestigationalMeropenem is a broad-spectrum carbapenem antibiotic. It is active against Gram-positive and Gram-negative bacteria. … Vabomere consists of meropenem and [DB12107] and is intravenously admininstered.
Categories: Heterocyclic Compounds, 2-RingSynonyms: (4R,5S,6S)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]thio}-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acidHydrocortamate
go.drugbank.com/drugs/DB00769ApprovedHydrocortamate is a synthetic glucocorticoid used for its anti-inflammatory or immunosuppressive properties to treat inflammation due to corticosteroid-responsive dermatoses. … Glucocorticoids are a class of steroid hormones characterised by an ability to bind with the cortisol receptor and trigger a variety of important cardiovascular, metabolic, immunologic and homeostatic
Categories: Cytochrome P-450 CYP3A Inducers, Cytochrome P-450 CYP3A4 InducersClidinium
go.drugbank.com/drugs/DB00771ApprovedClidinium is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. … It is used for the treatment of peptic ulcer disease and also to help relieve abdominal or stomach spasms or cramps due to colicky abdominal pain, diverticulitis, and irritable bowel syndrome.
Synonyms: 3-(2-Hydroxy-2,2-diphenyl-acetoxy)-1-methyl-1-azonia-bicyclo[2.2.2]octane, 3-hydroxy-1-methylquinuclidinium benzilate esterHydroflumethiazide
go.drugbank.com/drugs/DB00774ApprovedWithdrawnA thiazide diuretic with actions and uses similar to those of hydrochlorothiazide. (From Martindale, The Extra Pharmacopoeia, 30th ed, p822)
Categories: Heterocyclic Compounds, 2-RingPropiomazine
go.drugbank.com/drugs/DB00777ApprovedStructurally and pharmacologically similar to clozapine, propiomazine binds to alpha(1), dopamine, histamine H1, muscarinic, and serotonin type 2 (5-HT2) receptors. … Propiomazine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia.
Categories: Heterocyclic Compounds, 3-Ring, Adrenergic alpha-1 Receptor AntagonistsSynonyms: 10-(2-Dimethylaminopropyl)-2-propionylphenothiazine, 2-Propionyl-10-(2-(dimethylamino)propyl)phenothiazinePhenelzine
go.drugbank.com/drugs/DB00780ApprovedInvestigationalPhenelzine, with the formula β-phenylethylhydrazine, is a monoamine oxidase inhibiting antidepressant that is effective in the treatment of panic disorder and social anxiety disorder. … It is currently approved under prescription by the name of Nardil.
Categories: Cytochrome P-450 CYP2E1 Inducers, Monoamine Oxidase A SubstratesPropantheline
go.drugbank.com/drugs/DB00782ApprovedA muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking.
Categories: Heterocyclic Compounds, 3-Ring