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Granisetron
go.drugbank.com/drugs/DB00889ApprovedInvestigationalA serotonin receptor (5HT-3 selective) antagonist that has been used as an antiemetic and antinauseant for cancer chemotherapy patients.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: TİGRON 3 MG/3 ML İ.V. ENJEKSİYONLUK ÇÖZELTİ, 50 ADET, TİGRON 3 MG/3 ML İ.V. ENJEKSİYONLUK ÇÖZELTİ, 100 ADETDydrogesterone
go.drugbank.com/drugs/DB00378ApprovedInvestigationalWithdrawnA synthetic progestational hormone with no androgenic or estrogenic properties.
Synonyms: delta(6)-Retroprogesterone, 6-Dehydro-retro-progesteroneMixtures: Femoston conti 1 mg/5 mg Filmtabletten, Femoston conti 0,5 mg/2,5 mg FilmtablettenRibociclib
go.drugbank.com/drugs/DB11730ApprovedInvestigationalRibociclib is a selective cyclin-dependent kinase inhibitor, a class of drugs that help slow the progression of cancer by inhibiting two proteins called cyclin-dependent kinase 4 and 6 (CDK4/6). … Ribociclib was approved by the FDA in March 2017 under the brand name Kisqali.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A InhibitorsProducts: KISQALI (200 MG), KISQALI 200 MG TABLETAS RECUBIERTASMifepristone
go.drugbank.com/drugs/DB00834ApprovedInvestigationalThe two marketed forms of mifepristone are Mifeprex® (mifepristone 200mg) and Korlym™ (mifepristone 300mg). Currently under investigation for use in psychotic depression (phase 3 trials). … Mifepristone is a progestational and glucocorticoid hormone antagonist.
Categories: Genito Urinary System and Sex Hormones, Sex Hormones and Modulators of the Genital SystemProducts: MIFEPRISTONA 200 MG, MIFEPRISTONE 200 MGFavipiravir
go.drugbank.com/drugs/DB12466ApprovedInvestigationalDiscovered by Toyama Chemical Co., Ltd. in Japan, favipiravir is a modified pyrazine analog that was initially approved for therapeutic use in resistant cases of influenza. … [A191688,A191772,A191775] Not only does favipiravir inhibit replication of influenza A and B, but the drug has shown promise in the treatment of avian influenza, and may be an alternative option for
Categories: Cytochrome P-450 CYP2C8 Inhibitors, Cytochrome P-450 CYP2E1 InhibitorsProducts: KOVİPİR 200 MG FİLM KAPLI TABLET, 40 ADET, POLİCOVİR 200 MG FİLM KAPLI TABLET, 40 ADETBupropion
go.drugbank.com/drugs/DB01156ApprovedInvestigationalBupropion (also known as the brand name product Wellbutrin®) is a norepinephrine/dopamine-reuptake inhibitor (NDRI) used most commonly for the management of Major Depressive Disorder (MDD), Seasonal Affective … [L6562,A179038,A179050] The combination of naltrexone and bupropion was shown to result in a statistically significant weight loss, with a mean change in body weight of -6.3% compared to -1.3% for placebo
Mixtures: Appbutamone-DCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2B6 SubstratesRuxolitinib
go.drugbank.com/drugs/DB08877ApprovedInvestigational[A229938] Ruxolitinib was first approved for the treatment of adult patients with myelofibrosis by the FDA in 2011, followed by EMA's approval in 2012. … Ruxolitinib, formerly known as INCB018424 or INC424, is an anticancer drug and a Janus kinase (JAK) inhibitor.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesProducts: JAKAVI 20 MG (TABLETS), JAKAVI 20 MG TABLET, 168 TABLETAlendronic acid
go.drugbank.com/drugs/DB00630ApprovedInvestigationalIt functions by preventing resorption of bone[FDA Label][A959]. … Alendronic acid is a second generation bisphosphonate that is used for the treatment of some forms of osteoperosis and Paget's disease[FDA Label][A959,A203111].
Mixtures: Tridepos 70mg + 500 mg/800 I.E. Tabletten, FIXOSS 70 MG/5600 IU+1000 MG TEDAVI PAKETI 4+24 EFERVESAN TABLETSynonyms: (4-amino-1-hydroxybutylidene)bisphosphonic acid, 4-amino-1-hydroxybutane-1,1-diphosphonic acidLithium carbonate
go.drugbank.com/drugs/DB14509ApprovedInvestigationalLithium carbonate has a narrow therapeutic range and so careful monitoring is required to avoid adverse effects[FDA Label].
Categories: Drugs that are Mainly Renally Excreted with a Narrow Therapeutic IndexProducts: ESKALIT® SR 450 MG, THERALITE® 300 MGPrednisolone phosphate
go.drugbank.com/drugs/DB14631ApprovedInvestigationalVet approvedPrednisolone phosphate is a glucocorticoid similar to [cortisol] used for its anti-inflammatory, immunosuppressive, anti-neoplastic, and vasoconstrictive effects.
Mixtures: OFTALETYC® NFCategories: Cytochrome P-450 CYP2A6 Inducers, Cytochrome P-450 Substrates