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Dorzolamide
go.drugbank.com/drugs/DB00869ApprovedInvestigational[A1303] Unlike oral CA inhibitors, dorzolamide has negligible effects of acid-base or electrolyte disturbances and other systemic adverse effects. … [A1304] First marketed in 1995,[A190624] dorzolamide is available in ophthalmic solutions as monotherapy marketed as Trusopt [L11377] or in combination with [timolol] as Cosopt PF.[L11380]
Mixtures: Cosopt 20 mg/ml + 5 mg/ml Augentropfen, Dorzastad 20 mg/ml + 5 mg/ml AugentropfenCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2C9 SubstratesWarfarin
go.drugbank.com/drugs/DB00682ApprovedInvestigationalWarfarin is an anticoagulant drug normally used to prevent blood clot formation as well as migration. … Although originally marketed as a pesticide (d-Con, Rodex, among others), Warfarin has since become the most frequently prescribed oral anticoagulant in North America.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP1A2 SubstratesProducts: PLASORİN 10 MG TABLET, 28 ADET, WARFMADİN 10 MG TABLET, 28 ADETTolterodine
go.drugbank.com/drugs/DB01036ApprovedInvestigationalTolterodine acts on M2 and M3 subtypes of muscarinic receptors.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: DETRUSITOL 1 MG TABLET, 56 ADET, DETRUSITOL 2 MG TABLET, 56 ADETClemastine
go.drugbank.com/drugs/DB00283ApprovedInvestigationalAn ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness.
Categories: Cytochrome P-450 CYP2D6 Inhibitors, Cytochrome P-450 Enzyme InhibitorsProducts: TAVEGYL SURUP, 100 ML, TAVEGYL 1 MG TABLET, 20 ADETRoflumilast
go.drugbank.com/drugs/DB01656ApprovedInvestigational[A251385] PDE4 is a major cyclic-3',5′-adenosinemonophosphate (cyclic AMP, cAMP)-metabolizing enzyme [L37564] expressed on nearly all immune and pro-inflammatory cells, in addition to structural cells … The cream formulation was first approved by the FDA in July 2022 [L42580] and by Health Canada in April 2023.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesProducts: ROFLUNG 0,5 MG SAŞE ,30 SAŞE, ROFLUNG 0,5 MG SAŞE ,90 SAŞEEtilefrine
go.drugbank.com/drugs/DB08985ApprovedWithdrawnIt has been used as a vasoconstrictor agent.
Products: ETILEFRINACLORHIDRATO 10 MG /ML, ETILEFRINA CLORHIDRATO 10 MG/ MLDiflunisal
go.drugbank.com/drugs/DB00861ApprovedThough its mechanism of action has not been clearly established, most of its actions appear to be associated with inhibition of prostaglandin synthesis via the arachidonic acid pathway.
Synonyms: 5-(2,4-difluorophenyl)salicylic acid, 2-(hydroxy)-5-(2,4-difluorophenyl)benzoic acidProducts: Diflimax 500 mg Film Kaplı Tablet (10 adet), DOLPHIN 500 MG FILM KAPLI TABLET, 10 TABLETSecukinumab
go.drugbank.com/drugs/DB09029ApprovedInvestigationalSecukinumab is a fully human monoclonal IgG1/κ antibody against interleukin-17A (IL-17A), a proinflammatory cytokine implicated in various chronic immune-mediated inflammatory disorders, such as plaque … [A249805] It is currently approved to treat a number of chronic inflammatory conditions, such as plaque psoriasis, psoriatic arthritis, ankylosing spondylitis, and hidradenitis suppurativa.
Products: VERXANT 150 MG/1 ML ENJEKSİYONLUK ÇÖZELTİ İÇEREN KULLANIMA HAZIR KALEM, 2 ADET, VERXANT 150 MG/1 ML ENJEKSİYONLUK ÇÖZELTİ İÇEREN KULLANIMA HAZIR KALEM, 1 ADETAcebutolol
go.drugbank.com/drugs/DB01193ApprovedInvestigationalThe drug has stabilizing and quinidine-like effects on cardiac rhythm as well as weak inherent sympathomimetic action.
Synonyms: 5'-butyramido-2'-(2-hydroxy-3-isopropylaminopropoxy)acetophenoneCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2D6 InhibitorsAprotinin
go.drugbank.com/drugs/DB06692ApprovedInvestigationalWithdrawnSince it demonstrates the capacity to slow fibrinolysis, it has been employed to reduce bleeding during complex surgery such as heart and liver surgery. … Aprotinin is a protein-based drug that is also known as bovine pancreatic trypsin inhibitor (BPTI).
Mixtures: ARTISS 10 ML ÇÖZELTİ İÇEREN KULLANIMA HAZIR ENJEKTOR, 1 ADET, TISSEEL 10 ML ÇÖZELTİ İÇEREN KULLANIMA HAZIR ENJEKTÖR 1 ADETProducts: Trasylol 10 000 KIE/ml Infusionslösung, TRASYLOL INJECTION 500,000 kiu/50 ml