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Leucovorin
go.drugbank.com/drugs/DB00650ApprovedInvestigational[L56092, A257419] Unlike folic acid, leucovorin does not require the enzyme dihydrofolate reductase (DHFR) for activation, allowing it to function even when DHFR is inhibited by drugs like methotrexate … anemias resulting from folate deficiency when oral therapy is not feasible.
Synonyms: N-(5-formyl-5,6,7,8-tetrahydropteroyl)-L-glutamic acid, N5-Formyltetrahydrofolic acidMixtures: NEO CROMATON BICOMPLESSOPravastatin
go.drugbank.com/drugs/DB00175ApprovedInvestigationalIt was the first statin administered as the active form and not as a prodrug.[T274] This drug was developed by Sankyo Co. … The manufacturing process is followed by the hydrolysis of the lactone group and the biological hydroxylation with _Streptomyces carbophilus_ to introduce the allylic 6-alcohol group.[T239]
Mixtures: PRAVAFEN® CAPSULASCategories: P-glycoprotein substratesSertraline
go.drugbank.com/drugs/DB01104ApprovedInvestigationalSertraline is a popular antidepressant medication commonly known as a selective serotonin reuptake inhibitor (SSRI), and is similar to drugs such as [Citalopram] and [Fluoxetine]. … Despite marked structural differences between compounds in this drug class, SSRIs exert similar pharmacological effects.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, P-glycoprotein inhibitorsSynonyms: (1S-cis)-1,2,3,4-tetrahydro-4-(3,4-dichlorophenyl)-N-methyl-1-naphthalenamineTestosterone enanthate
go.drugbank.com/drugs/DB13944ApprovedInvestigationalThis slow release is achieved by the presence of the enanthate ester functional group attached to the testosterone molecule. … The majority of the prescriptions written were for injectable (66%) and topical (32%) testosterone products. As recent as 1 October 2018, the US FDA approved Antares Pharma Inc.'
Mixtures: Neo Pause Injection, NOFERTYL® INYECTABLECategories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesHaemangioma
go.drugbank.com/conditions/DBCOND0017266Synonyms: Hemangioma, no ICD-O subtype, Hemangioma, no International Classification of Diseases for Oncology subtypeEtrasimod
go.drugbank.com/drugs/DB14766ApprovedInvestigational[A261826] In fact, it has been observed that antigen-activated T cells within peripheral lymphoid organs can transiently downregulate S1P receptor levels to facilitate immune cells trafficking into the … [A261831] Etrasimod was approved on October 13, 2023, by the FDA under the brand name VELSIPITY for the treatment of adults with moderately to severely active ulcerative colitis.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 2-RingCutaneous Squamous Cell Carcinoma (CSCC)
go.drugbank.com/conditions/DBCOND0168836Drugs: CemiplimabSynonyms: Squamous cell carcinoma, no ICD-O subtype, Squamous cell carcinoma, no International Classification of Diseases for Oncology subtypeDNA-3-methyladenine glycosylase 1
go.drugbank.com/bio_entities/BE0001657TargetEscherichia coli (strain K12)Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine from the damaged DNA polymer formed by alkylation lesions.
Synonyms: TAG I, DNA-3-methyladenine glycosidase IOlmesartan
go.drugbank.com/drugs/DB00275ApprovedInvestigationalangiotensin I to angiotensin II through inhibition of the ACE enzyme. … [A175330] It was developed by Daiichi Sankyo Pharmaceuticals and approved in 2002.[A175345, L12882]
Synonyms: 4-(1-hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acid, 4-(hydroxy-1-methylethyl)-2-propyl-1-{[2'-(1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylic acidMixtures: OPENVAS CO, ALMETEC-CORisperidone
go.drugbank.com/drugs/DB00734ApprovedInvestigational[L12885] Schizophrenia and various mood disorders are thought to be caused by an excess of dopaminergic D2 and serotonergic 5-HT2A activity, resulting in overactivity of central mesolimbic pathways … Risperidone is thought to reduce this overactivity through inhibition of dopaminergic D2 receptors and serotonergic 5-HT2A receptors in the brain.
Categories: Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome, P-glycoprotein substratesInternational brands: Risperidal M-Tab