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Displaying results 861 - 870 of 10000 in total
  1. Drug

    Clemastine

    go.drugbank.com/drugs/DB00283
    ApprovedInvestigational

    An ethanolamine-derivative, first generation histamine H1 antagonist used in hay fever, rhinitis, allergic skin conditions, and pruritus. It causes drowsiness.

    Mixtures: Tavist-D TabletsCategories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 CYP2D6 Inhibitors
  2. Drug

    Rotavirus vaccine

    go.drugbank.com/drugs/DB10276
    ApprovedInvestigational

    Rotateq is a live vaccine consisting of 5 reassorted human-bovine viral strains.[L1116] Rotarix is a live attenuated vaccine containing the 89-12 human strain.

    Salts: Human Rotavirus A type G1P7(5) strain WI79 live antigen, Human Rotavirus A type G2P7(5) strain SC2 live antigenMixtures: ROTATEQ® VACUNA ORAL PENTAVALENTE CONTRAROTAVIRUS, ROTATEQ® VACUNA ORAL PENTAVALENTE CONTRAROTAVIRUS
  3. Drug

    Oxaliplatin

    go.drugbank.com/drugs/DB00526
    ApprovedInvestigational

    Oxaliplatin is a platinum-based chemotherapy drug in the same family as cisplatin and carboplatin. … Compared to cisplatin the two amine groups are replaced by diamino cyclohexane (DACH) group to provide a greater antitumor effect.

    Categories: OCT2 Substrates with a Narrow Therapeutic IndexSynonyms: L-OHP, (SP-4-2-(1R-TRANS))-(1,2-CYCLOHEXANEDIAMINE-N,N')(ETHANEDIOATO(2-)-O,O')PLATINUM
  4. Drug

    Rotigotine

    go.drugbank.com/drugs/DB05271
    ApprovedInvestigational

    It is formulated as a once-daily transdermal patch which provides a slow and constant supply of the drug over the course of 24 hours. … However, all Neupro patches in the United States and some of Europe were recalled in 2008 due to delivery mechanism issues. Rotigotine has been authorized as a treatment for RLS since August 2008.

    Mixtures: NEUPRO TRANSDERMAL 28 FLASTER BASLANGIC TEDAVI PAKETI, NEUPRO TRANSDERMAL 28 FLASTER BASLANGIC TEDAVI PAKETICategories: Serotonin 5-HT1 Receptor Agonists, Cytochrome P-450 Substrates
  5. Drug

    Clobazam

    go.drugbank.com/drugs/DB00349
    ApprovedIllicitInvestigational

    [A256963,A256868] This is likely because of clobazam's higher affinity to the α<sub>2</sub> subunit of the GABA<sub>A</sub> receptor, which mediates anxiolytic effects, than the α<sub>1</sub> subunit, … [A256868] Additionally, clobazam is believed to be a partial agonist to the GABA<sub>A</sub> receptor rather than non-selective full receptor agonists like 1,4-benzodiazepines, thus potentially explaining

    Synonyms: 7-Chloro-1-methyl-5-phenyl-1,5-dihydro-benzo[b][1,4]diazepine-2,4-dione, 1-phenyl-5-methyl-8-chloro-1,2,4,5-tetrahydro-2,4-dioxo-3H-1,5-benzodiazepineCategories: Heterocyclic Compounds, 2-Ring, GABA-A Receptor Agonists
  6. Drug

    5-(7-(6-chloro-4-(5-hydro-4-methyl-2-oxazolyl)phenoxy)heptyl)-3-methyl isoxazole

    go.drugbank.com/drugs/DB08722
    Experimental

    5-(7-(6-chloro-4-(5-hydro-4-methyl-2-oxazolyl)phenoxy)heptyl)-3-methyl isoxazole is a solid. This compound belongs to the phenol ethers. … These are aromatic compounds containing an ether group substituted with a benzene ring. 5-(7-(6-chloro-4-(5-hydro-4-methyl-2-oxazolyl)phenoxy)heptyl)-3-methyl isoxazole targets the protein genome polyprotein

    Synonyms: 5-(7-(6-chloro-4-(5-hydro-4-methyl-2-oxazolyl)phenoxy)heptyl)-3-methyl isoxazole
  7. Drug

    Phenoxyethanol

    go.drugbank.com/drugs/DB11304
    ApprovedInvestigational

    It is produced by reacting phenol (EU) and ethylene oxide (EU) at a high temperature and pressure. This substance occurs naturally in green tea (EU) [L2621]. … Phenoxyethanol is a colorless liquid with a pleasant odor.

    Mixtures: Linola sept 1 mg/g + 10 mg/g Wund-Gel, Linola sept 1 mg/g + 20 mg/g Wund-Spray zur Anwendung auf der Haut, LösungSynonyms: 1-Hydroxy-2-phenoxyethane, 2-phenoxyethanol
  8. Drug

    Viloxazine

    go.drugbank.com/drugs/DB09185
    ApprovedInvestigationalWithdrawn

    Viloxazine is a selective norepinephrine reuptake inhibitor.[L41685] For decades, an immediate-release formulation of viloxazine has been used in Europe as an antidepressant. … It was first approved in the UK in 1974; however, the immediate-release formulation was discontinued due to business reasons unrelated to drug safety and efficacy.

    Categories: MATE 1 Inhibitors, Cytochrome P-450 SubstratesSynonyms: 2-((2-Ethoxyphenoxy)methyl)morpholine
  9. Drug

    Iohexol

    go.drugbank.com/drugs/DB01362
    ApprovedInvestigational

    Iohexol is an effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chem...

    Synonyms: N,N'-Bis(2,3-dihydroxypropyl)-5-(N-(2,3-dihydroxypropyl)acetamido)-2,4,6-triiodoisophthalamideMixtures: Dexlido M-C, Dyural LM- C
  10. Drug

    Phosporic Acid Mono-[3,4-Dihydroxy-5-(5-Methoxy-Benzoimidazol-1-Yl)-Tetrahydro-Furan-2-Ylmethyl] Ester

    go.drugbank.com/drugs/DB04176
    Experimental

    Synonyms: Phosporic Acid Mono-[3,4-Dihydroxy-5-(5-Methoxy-Benzoimidazol-1-Yl)-Tetrahydro-Furan-2-Ylmethyl] Ester