Search
Fluvastatin
go.drugbank.com/drugs/DB01095ApprovedInvestigationalFluvastatin is a racemate comprising equimolar amounts of (3R,5S)- and (3S,5R)-fluvastatin. … Fluvastatin is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase.
Categories: Cytochrome P-450 CYP2B6 Inducers, Cytochrome P-450 CYP1A1 SubstratesCapecitabine
go.drugbank.com/drugs/DB01101ApprovedInvestigationalCapecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue. … Capecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers.
Categories: Cytochrome P-450 CYP2C9 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 SubstratesSynonyms: Pentyl [1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl]carbamate, pentyl 1-(5-deoxy-β-D-ribofuranosyl)-5-fluoro-1,2-dihydro-2-oxo-4-pyrimidinecarbamateQuinacrine
go.drugbank.com/drugs/DB01103InvestigationalIt has also been used as an anthelmintic and in the treatment of giardiasis and malignant effusions. It is used in cell biological experiments as an inhibitor of phospholipase A2. … An acridine derivative formerly widely used as an antimalarial but superseded by chloroquine in recent years.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesSynonyms: 3-chloro-7-methoxy-9-(1-methyl-4-diethylaminobutylamino)acridine, 6-chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxyacridineCefuroxime
go.drugbank.com/drugs/DB01112ApprovedInvestigationalBroad-spectrum cephalosporin antibiotic resistant to beta-lactamase. It has been proposed for infections with gram-negative and gram-positive organisms, gonorrhea, and haemophilus.
Mixtures: TUGENS 250 MG IM ENJEKSIYON ICIN TOZ ICEREN FLAKON, 1 ADET, TUGENS 750 MG IM ENJEKSIYON ICIN TOZ ICEREN FLAKON, 1 ADETCategories: Heterocyclic Compounds, 2-RingPapaverine
go.drugbank.com/drugs/DB01113ApprovedInvestigationalIt is a direct-acting smooth muscle relaxant used in the treatment of impotence and as a vasodilator, especially for cerebral vasodilation. … The mechanism of its pharmacological actions is not clear, but it apparently can inhibit phosphodiesterases and it may have direct actions on calcium channels.
Categories: Heterocyclic Compounds, 2-RingProducts: PAPAVERIN HIDROKLORUR 0.04 G/2 ML BIOSEL AMPUL, 10 ADET, PAPAVERIN HIDROKLORUR 0.05 G/2 ML BIOSEL AMPUL, 10 ADETAmiodarone
go.drugbank.com/drugs/DB01118ApprovedInvestigationalAmiodarone is a benzofuran derivative, anti-arrhythmic drug used commonly in a variety of settings. … [A36817] Most known for its approved indication in life-threatening ventricular arrhythmias, it is also used off-label in the outpatient and inpatient setting for atrial fibrillation.
Categories: Cytochrome P-450 CYP2C8 Substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic IndexSynonyms: 2-n-Butyl-3',5'-diiodo-4'-N-diethylaminoethoxy-3-benzoylbenzofuran, 2-Butyl-3-(3,5-diiodo-4-(2-diethylaminoethoxy)benzoyl)benzofuranRabeprazole
go.drugbank.com/drugs/DB01129ApprovedInvestigationalRabeprazole is an antiulcer drug in the class of proton pump inhibitors. It is a prodrug - in the acid environment of the parietal cells it turns into active sulphenamide form. … Rabeprazole inhibits the H+, K+ATPase of the coating gastric cells and dose-dependent oppresses basal and stimulated gastric acid secretion.
Categories: Cytochrome P-450 Substrates, 2-PyridinylmethylsulfinylbenzimidazolesProducts: Raberprazole Sodium D/r, PARIET ® TABLETAS DE 20 MGDesoxycorticosterone pivalate
go.drugbank.com/drugs/DB01134ExperimentalVet approvedDesoxycorticosterone pivalate is a mineralocorticoid hormone and an analog of desoxycorticosterone. It is white, odorless, and stable in air. … Federal (U.S.A.) law restricts this drug to use by or on the order of a licensed veterinarian.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesInternational brands: Cortexone M, Percorten MDoxepin
go.drugbank.com/drugs/DB01142ApprovedInvestigational[T559] It is a tertiary amine that can be presented as (E) and (Z) stereoisomers with the (Z) stereoisomer corresponding to [cidoxepin]. Doxepin commonly produces a 5:1 (E):(Z) racemic mixture. … Doxepin is a psychotropic agent with antidepressant and anxiolytic properties.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesProducts: PURDOX %5 KREM, 30 G, EXPAN® 50 MGPimavanserin
go.drugbank.com/drugs/DB05316ApprovedInvestigationalIn fact, pimavanserin is the first antipsychotic drug without D<sub>2</sub> blocking activity. … [L48236] Although the exact mechanism of action is unknown, it is thought that pimavanserin interacts with the serotonin receptors, particularly the 5-HT<sub>2A</sub> and HT<sub>2C</sub> receptors.
Categories: Cytochrome P-450 Substrates, Heterocyclic Compounds, 1-Ring