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Displaying results 8841 - 8850 of 10000 in total
  1. Drug

    Dirocaftor

    go.drugbank.com/drugs/DB16143
    Investigational

    Dirocaftor is under investigation in clinical trial NCT03251092 (Study Designed to Assess the Safety, Tolerability and PK of PTI-808 in Healthy Volunteers and in Adults With Cystic Fibrosis).

  2. Drug

    Domvanalimab

    go.drugbank.com/drugs/DB18848
    Investigational

    Domvanalimab is under investigation in clinical trial NCT05502237 (Zimberelimab and Domvanalimab in Combination With Chemotherapy Versus Pembrolizumab With Chemotherapy in Patients With Untreated Metastatic

    Synonyms: Immunoglobulin g1 (236-alanine,237-alanine,de-c-terminal-lysine), anti-(human receptor tigit)(human-mus musculus monoclonal ab154 .gamma.1-chain), disulfide with human-mus musculus monoclonal ab154 .kappa
  3. Drug

    Quisovalimab

    go.drugbank.com/drugs/DB16482
    Investigational

  4. Drug

    Gevokizumab

    go.drugbank.com/drugs/DB12119
    Investigational

    Gevokizumab acts as a modulator of cytokine imbalance in IL-1 mediated disease states. It has a very high binding affinity of 300fM and blocks the activation of IL-1 receptors. … Gevokizumab has been used in trials studying the treatment of Acne Vulgaris, Osteoarthritis, Behcet's Uveitis, Pyoderma Gangrenosum, and Behcet's Disease Uveitis, among others.

  5. Drug

    GSK-945237

    go.drugbank.com/drugs/DB15345
    Investigational

    GSK-945237 is under investigation in clinical trial NCT01039610 (A Single Center Four Part Study in Healthy Adult Subjects to Evaluate: the Safety, Tolerability and Pharmacokinetics of a Single Oral Dose … and Repeat Escalating Oral Doses of GSK945237; the Effect of Linezolid on Hematology Safety Parameters; and the Effects of GSK945237 and Moxifloxacin on QTc.).

  6. Drug

    Edivoxetine

    go.drugbank.com/drugs/DB09184
    Investigational

    Edivoxetine failed to be approved for major depressive disorder after phase III clinical trials in 2012. … Edivoxetine is a drug which acts as a selective norepinephrine reuptake inhibitor and is currently under development by Eli Lilly for attention-deficit hyperactivity disorder (ADHD) and as an antidepressant

    Categories: Heterocyclic Compounds, 1-Ring
  7. Drug

    Epitestosterone

    go.drugbank.com/drugs/DB07768
    Experimental

    Epitestosterone acts as an antiandrogen in various target tissues. The ratio between testosterone/epitestosterone is used to monitor anabolic drug abuse. … Epitestosterone is the 17-alpha isomer of testosterone, derived from pregnenolone via the delta5-steroid pathway, and via 5-androstene-3-beta,17-alpha-diol.

    Synonyms: 17-alpha-Hydroxyandrost-4-en-3-one, (17-alpha)-17-Hydroxyandrost-4-en-3-one
  8. Drug

    Fuzapladib

    go.drugbank.com/drugs/DB19478
    Experimental

    Fuzapladib is a small molecule drug. The usage of the INN stem '-pladib' in the name indicates that Fuzapladib is a phospholipase A2​ inhibitor. … Fuzapladib has a monoisotopic molecular weight of 379.12 Da.

    Categories: Heterocyclic Compounds, 1-Ring, Phospholipases A, antagonists & inhibitors
  9. Drug

    Umibecestat

    go.drugbank.com/drugs/DB19898
    Experimental

    Umibecestat is a small molecule drug. The usage of the INN stem '-becestat' in the name indicates that Umibecestat is a beta secretase inhibitor. … Umibecestat has a monoisotopic molecular weight of 513.08 Da.

    Categories: Heterocyclic Compounds, 1-Ring
  10. Drug

    Zaloglanstat

    go.drugbank.com/drugs/DB21495
    Experimental

    Zaloglanstat is a small molecule drug. The usage of the INN stem '-glanstat' in the name indicates that Zaloglanstat is a prostaglandin synthase inhibitor. … Zaloglanstat has a monoisotopic molecular weight of 452.12 Da.