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Displaying results 8891 - 8900 of 10000 in total
  1. Drug

    OSI-027

    go.drugbank.com/drugs/DB12387
    Investigational

    OSI-027 has been used in trials studying the treatment of Any Solid Tumor or Lymphoma.

    Synonyms: CYCLOHEXANECARBOXYLIC ACID, 4-(4-AMINO-5-(7-METHOXY-1H-INDOL-2-YL)IMIDAZO(5,1-F)(1,2,4)TRIAZIN-7-YL)-, TRANS-Categories: Heterocyclic Compounds, 1-Ring
  2. Drug

    Evocalcet

    go.drugbank.com/drugs/DB12388
    Investigational

    Evocalcet has been used in trials studying the treatment of Hyperparathyroidism and Secondary Hyperparathyroidism.

    Categories: Heterocyclic Compounds, 1-Ring
  3. Drug

    Seladelpar

    go.drugbank.com/drugs/DB12390
    ApprovedInvestigational

    Seladelpar is a peroxisome proliferator-activated receptor (PPAR)-delta (δ) agonist. Seladelpar is a single enantiomer of the R-configuration. … [L51149] On August 14, 2024, seladelpar was granted accelerated approval by the FDA for the treatment of primary biliary cholangitis,[L51154] which is a condition associated with aberrant bile acid metabolism

    Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesSynonyms: (R)-2-(4-((2-ETHOXY-3-(4-(TRIFLUOROMETHYL)PHENOXY)PROPYL)-THIO)-2-METHYLPHENOXY)ACETIC ACID, ((4-(((2R)-2-ETHOXY-3-(4-(TRIFLUOROMETHYL)PHENOXY)PROPYL)THIO)-2-METHYLPHENYL)OXY)ACETIC ACID
  4. Drug

    Sagopilone

    go.drugbank.com/drugs/DB12391
    Investigational

    It is a so-called fully synthetic epothilone and is the first such compound to be in clinical development to combat several forms of cancer. … Epothilones are 16-member ring macrolides with antimicrotubule activity that share a similar mechanism of action to the taxanes but have demonstrated potent antiproliferative activity in several different

    Categories: Cytochrome P-450 CYP3A Inhibitors, Heterocyclic Compounds, 1-Ring
  5. Drug

    Remimazolam

    go.drugbank.com/drugs/DB12404
    ApprovedInvestigational

    [L14647] Recent trends in anesthesia-related drug development have touted the benefits of so-called "soft drugs" - these agents, such as [remifentanil], are designed to be metabolically fragile and thus … [A214857] These "soft drugs" are useful in the context of surgical procedures, wherein a rapid onset/offset is desirable, enabling anesthesiologists to manipulate drug concentrations as needed.

    Categories: Heterocyclic Compounds, 2-Ring
  6. Drug

    Gemigliptin

    go.drugbank.com/drugs/DB12412
    Investigational

    Gemigliptin is under investigation in Type 2 Diabetes Mellitus. Gemigliptin has been investigated for the treatment of Cancer and Cisplatin Adverse Reaction.

    Categories: Heterocyclic Compounds, 1-Ring, Diabetes Mellitus, Type 2, drug therapy
  7. Drug

    VTP-27999

    go.drugbank.com/drugs/DB12416
    Investigational

    VTP-27999 has been used in trials studying the basic science of Renal Function.

    Categories: Heterocyclic Compounds, 1-Ring
  8. Drug

    Sulforaphane

    go.drugbank.com/drugs/DB12422
    Investigational

    Sulforaphane is under investigation for the treatment of Autism Spectrum Disorder. It is a naturally occurring isothiocyanate found in high concentration in a variety of broccoli.

    Categories: Cytochrome P-450 CYP2E1 Inhibitors, Cytochrome P-450 Enzyme InhibitorsSynonyms: (R)-sulforaphane, 4-methylsulfinylbutyl isothiocyanate
  9. Drug

    Bitopertin

    go.drugbank.com/drugs/DB12426
    Investigational

    Bitopertin has been used in trials studying the treatment of Schizophrenia and Obsessive-Compulsive Disorder.

    Categories: Heterocyclic Compounds, 1-Ring
  10. Drug

    Tipelukast

    go.drugbank.com/drugs/DB12435
    Investigational

    Tipelukast is under investigation for the treatment of IPF and Idiopathic pulmonary fibrosis.