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Melatonin
go.drugbank.com/drugs/DB01065ApprovedInvestigationalNutraceuticalVet approvedMelatonin is a biogenic amine that is found in animals, plants and microbes. Aaron B. Lerner of Yale University is credited for naming the hormone and for defining its chemical structure in 1958. … The pineal gland is small endocrine gland, about the size of a rice grain and shaped like a pine cone (hence the name), that is located in the center of the brain (rostro-dorsal to the superior colliculus
Synonyms: 5-methoxy-N-acetyl tryptamine, 5-methoxy-N-acetyltryptamineInternational brands: Mela-TIsosorbide mononitrate
go.drugbank.com/drugs/DB01020ApprovedInvestigational[L11743] Isosorbide mononitrate has a longer duration of action than [nitroglycerin] due to its slow onset of absorption and metabolism. … It is an anti-anginal agent that works by relaxing the smooth muscles of both arteries and veins, but but predominantly veins to reduce cardiac preload.
Synonyms: IS 5-MN, IS-5-MNProducts: IS 5 MONO RATIO 40MG RET, IS 5 MONO RATIO 60MG RETDoxorubicin
go.drugbank.com/drugs/DB00997ApprovedInvestigational[A257709] Although its detailed molecular mechanisms have yet to be understood, doxorubicin is generally thought to exert its effect through DNA intercalation, which eventually leads to DNA damage and … Doxorubicin is a cytotoxic anthracycline antibiotic isolated from cultures of Streptomyces peucetius var. caesius along side with daunorubicin, another cytotoxic agent, in 1970.
Categories: P-glycoprotein substrates with a Narrow Therapeutic Index, Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic IndexSynonyms: (1S,3S)-3-glycoloyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside, (8S-cis)-10-((3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedioneAminacrine
go.drugbank.com/drugs/DB11561InvestigationalA highly fluorescent anti-infective dye used clinically as a topical antiseptic and experimentally as a mutagen, due to its interaction with DNA. It is also used as an intracellular pH indicator.
Categories: Heterocyclic Compounds, 3-Ring, Compounds used in a research, industrial, or household settingSynonyms: 10-amino-5-azaanthracene, 5-aminoacridineFlavin mononucleotide
go.drugbank.com/drugs/DB03247ApprovedInvestigationalFlavin mononucleotide (FMN), also known as riboflavin 5'-phosphate, is one of the two major coenzymes derived from [riboflavin] (vitamin B2) and is one of the principal forms in which dietary riboflavin … [L54241] Alongside [flavin adenine dinucleotide] (FAD), for which it is a direct precursor, FMN plays critical roles in energy production, cellular function, and in the metabolism of fats, drugs, and steroids
Synonyms: riboflavin 5'-phosphate, Riboflavin-5-phosphateSalts: Riboflavin 5'-phosphate sodium anhydrous, Riboflavin-5'-phosphate sodium salt dihydrateDienogest
go.drugbank.com/drugs/DB09123ApprovedInvestigationalIt is a derivative of 19-nortestosterone and has antiandrogenic properties. … It is primarily used as a contraceptive in combination with ethinylestradiol, or in other combination form pills approved in United States and Europe however it is not available in the US by itself.
Mixtures: VELBIENNE® 10, ACOTOL EXCategories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesPralatrexate
go.drugbank.com/drugs/DB06813ApprovedInvestigationalPralatrexate is an antifolate for the treatment of relapsed or refractory peripheral T-cell lymphoma [L37674]. … [L37674] It is also being studied for other types of lymphoma and solid malignancy such as non-small-cell lung cancer, breast cancer, and bladder cancer.[A246678]
Categories: Heterocyclic Compounds, 2-RingSynonyms: 10-Propargyl-10-deazaaminopterin, N-(4-(1-((2,4-Diamino-6-pteridinyl)methyl)-3-butynyl)benzoyl)-L-glutamic acidCiticoline
go.drugbank.com/drugs/DB12153ApprovedInvestigationalWithdrawnCiticoline is a donor of choline in biosynthesis of choline-containing phosphoglycerides. … It has been investigated for the treatment, supportive care, and diagnosis of Mania, Stroke, Hypomania, Cocaine Abuse, and Bipolar Disorder, among others.
Categories: Heterocyclic Compounds, 1-RingSynonyms: Cytidine 5'-diphosphocholine, Cytidine-5'-diphosphocholinePentobarbital
go.drugbank.com/drugs/DB00312ApprovedVet approvedA short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. … It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration.
Categories: Heterocyclic Compounds, 1-Ring, Cytochrome P-450 SubstratesSynonyms: 5-Ethyl-5-(1-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione, 5-ethyl-5-(1-methylbutyl)barbituric acidFurosemide
go.drugbank.com/drugs/DB00695ApprovedInvestigationalVet approvedFurosemide is a potent loop diuretic that acts on the kidneys to ultimately increase water loss from the body. It is an anthranilic acid derivative. … [A182495] The use of furosemide is particularly beneficial in clinical settings that require a drug with a higher diuretic potential.
Mixtures: Lasitace 5 mg/40 mg Kapseln, Lasitace 5 mg/20 mg KapselnCategories: Increased Diuresis at Loop of Henle