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Etoposide
go.drugbank.com/drugs/DB00773ApprovedInvestigationalEtoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. … Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
Categories: Antineoplastic and Immunomodulating AgentsInternational brands: Vepesid KCortisone acetate
go.drugbank.com/drugs/DB01380ApprovedInvestigationalgastrointestinal diseases and disorders. … Cortisone acetate was first isolate in 1935 and became more widely researched in 1949.
Categories: Hormones, Hormone Substitutes, and Hormone AntagonistsProducts: Cortone Tab 25mg, Cortone Sus 50mg/mlMethyldopa
go.drugbank.com/drugs/DB00968ApprovedInvestigational[A1499] Methyldopa exists in two isomers D-α-methyldopa and L-α-methyldopa, which is the active form. … Methyldopa works by binding to alpha(α)-2 adrenergic receptors as an agonist, leading to the inhibition of adrenergic neuronal outflow and reduction of vasoconstrictor adrenergic signals.
Mixtures: Methyldopa and Hydrochlorothiazide, Methyldopa and HydrochlorothiazideCategories: Amino Acids, Peptides, and ProteinsCapecitabine
go.drugbank.com/drugs/DB01101ApprovedInvestigationalCapecitabine is an orally-administered chemotherapeutic agent used in the treatment of metastatic breast and colorectal cancers. … Capecitabine is a prodrug, that is enzymatically converted to fluorouracil (antimetabolite) in the tumor, where it inhibits DNA synthesis and slows growth of tumor tissue.
Categories: Fluorouracil and prodrugs, Antineoplastic and Immunomodulating AgentsProducts: Capecitabine 150mg, XELODA 150MGCrizotinib
go.drugbank.com/drugs/DB08865ApprovedInvestigational[A250785] Crizotinib was approved by the FDA in 2011, and its use is accompanied by FDA-approved tests used to detect ALK and ROS1 rearrangements.[L42460] … Second- and third-generation ALK-tyrosine kinase-inhibitors have overcome many of the pharmacodynamic and genetic resistance mechanisms crizotinib is prone to.
Categories: Antineoplastic and Immunomodulating AgentsProducts: Xalkori Capsules 250mg, Xalkori 250mg Hard CapsulesCinnarizine
go.drugbank.com/drugs/DB00568ApprovedInvestigationalFirst synthesized by Janssen Pharmaceuticals in 1955, cinnarizine is an anti-histaminic drug mainly used for the control of vestibular disorders and motion sickness. … Cinnarizine is a specific calcium channel blocker that primarily works on the central vestibular system to interfere with the signal transmission between vestibular apparatus of the inner ear and the vomiting
Categories: Calcium-Regulating Hormones and AgentsProducts: PRINAZIN TABLET 25MG, STUGERON 25MG TABLETSodium bicarbonate
go.drugbank.com/drugs/DB01390ApprovedInvestigationalSodium bicarbonate is a white, crystalline powder that is commonly used as a pH buffering agent, an electrolyte replenisher, systemic alkalizer and in topical cleansing solutions.
Mixtures: Up and Up Antacid and Pain Relief, MILACID® SACHET POR 10ML SABOR MENTACategories: Antacids and Adsorbents, Blood and Blood Forming OrgansNicardipine
go.drugbank.com/drugs/DB00622ApprovedInvestigationalIt has antihypertensive properties and is effective in the treatment of angina and coronary spasms without showing cardiodepressant effects. … It has also been used in the treatment of asthma and enhances the action of specific antineoplastic agents. [PubChem]
Categories: Calcium-Regulating Hormones and AgentsProducts: Cardene 20mg Capsules, Nicardiin 1mg/ml Solution for InfusionEupatorium capillifolium pollen
go.drugbank.com/drugs/DB10468ApprovedEupatorium capillifolium pollen is the pollen of the Eupatorium capillifolium plant. Eupatorium capillifolium pollen is mainly used in allergenic testing.
Products: Pollens - Weeds and Garden Plants, Dog Fennel Eupatorium capillifolium, Pollens - Weeds and Garden Plants, Dog Fennel, Eastern Eupatorium capillifolium