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Methylnaltrexone
go.drugbank.com/drugs/DB06800ApprovedInvestigationalMethylnaltrexone is a pheriphally-acting μ-opioid antagonist that acts on the gastrointestinal tract to decrease opioid-induced constipation without producing analgesic effects or withdrawal symptoms. … It is also a weak CYP2D6 inhibitor. FDA approved in 2008.
Categories: Drugs for Constipation, Heterocyclic Compounds with 4 or More RingsProducts: Relistor Solution For Injection 12mg/0.6mLEphedra sinica root
go.drugbank.com/drugs/DB01363ApprovedNutraceuticalThe sale of ephedra-containing supplements intended to increase muscle weight or promote weight loss was banned in the United States in 2004 due to the risk for adverse effects and a lack of evidence for … The drug is still sold in Canada in OTC formulations for respiratory conditions associated with bronchial asthma.
Mixtures: Miller's Formula No. 1Categories: Monoamine Oxidase A Inhibitors for interaction with Monoamine Oxidase A substratesCaptopril
go.drugbank.com/drugs/DB01197ApprovedInvestigationalCaptopril is a potent, competitive inhibitor of angiotensin-converting enzyme (ACE), the enzyme responsible for the conversion of angiotensin I (ATI) to angiotensin II (ATII). … ATII regulates blood pressure and is a key component of the renin-angiotensin-aldosterone system (RAAS). Captopril may be used in the treatment of hypertension.
Mixtures: CO-ALTIVERCategories: Agents Acting on the Renin-Angiotensin System, Antihypertensive Agents Indicated for HypertensionChoriogonadotropin alfa
go.drugbank.com/drugs/DB00097ApprovedInvestigationalThe primary structure of the alpha-chain of r-hCG is identical to that of the alpha-chain of hCG, FSH and LH. … Recombinant human chorionic gonadotropin with 2 subunits, alpha = 92 residues, beta = 145 residues, each with N-and O-linked carbohydrate moieties linked to ASN-52 and ASN-78 (on alpha subunit) and ASN
Products: Ovidrel Solution for Injection 250 mcg, OVIDREL 250MCG/0.5ML SOLUTION FOR INJECTIONBordetella pertussis filamentous hemagglutinin antigen (formaldehyde inactivated)
go.drugbank.com/drugs/DB10788ApprovedInvestigationalBordetella pertussis filamentous hemagglutinin antigen (formaldehyde inactivated) is a vaccine that contains inactivated acellular pertussis antigen that is isolated from Bordetella pertussis culture.
Mixtures: -POLIO SUSPENSION FOR INJECTION IN PRE-FILLED SYRINGE, , Suspension for InjectionProducts: PERTAGEN® SUSPENSION FOR INJECTION 0.5 ML/DOSEEdetate calcium disodium anhydrous
go.drugbank.com/drugs/DB14598ApprovedInvestigational[L12774] It is on the World Health Organization Model List of Essential Medicines.[A204173] Edetate calcium disodium was granted FDA approval on 16 July 1953.[L12774] … Edetate calcium disodium is a metal ion chelator used to reduce blood concentrations and depot stores of lead from the body.
Categories: Compounds used in a research, industrial, or household settingSynonyms: Edetic acid calcium disodium saltIxabepilone
go.drugbank.com/drugs/DB04845ApprovedInvestigationalIt was FDA approved on October 16, 2007, for the treatment of unresponsive aggressive metastatic or locally advanced breast cancer. … It has a lactone–lactam modification that minimizes susceptibility to esterase degradation.
Products: IXEMPRA FOR INJECTION 15 MG, IXEMPRA (FOR INJECTION 15 MG)Calcium polycarbophil
go.drugbank.com/drugs/DB14684ApprovedPolycarbophil is used to treat constipation. This drug may also be used to help relieve the symptoms of irritable bowel syndrome or diarrhea. … Less gas and bloating compared to psyllium laxative products, but can cause heartburn, and belly cramps. It is insoluble in water, dilute acids, and dilute alkali.
Categories: Compounds used in a research, industrial, or household setting, Drugs for ConstipationProducts: Fiber-ON-tablet, Up and Up Fiber TherapyMiconazole
go.drugbank.com/drugs/DB01110ApprovedInvestigationalVet approved[A203636, A203639] Miconazole was first synthesized in 1969 and first granted FDA approval on January 8, 1974, for sale by INSIGHT Pharmaceuticals as a topical cream. … Despite having been in clinical use for an extended period, resistance to miconazole among susceptible organisms is relatively low.[A203636]
Mixtures: Monistat 3 Combination Pack 3-Day in Pre-Filled Applicators, Monistat 3 Combination Pack 3-Day in Pre-Filled ApplicatorsCategories: Antifungals for Topical Use, Antifungals for Dermatological UseEtelcalcetide
go.drugbank.com/drugs/DB12865ApprovedInvestigationalEtelcalcetide was approved (trade name Parsabiv) for the treatment of secondary hyperparathyroidism (HPT) in adult patients with chronic kidney disease (CKD) on hemodialysis in February, 2017. … Etelcalcetide is a calcimimetic drug for the treatment of secondary hyperparathyroidism in patients undergoing hemodialysis.
Products: Parsabiv 5mg solution for injection, PARSABIV SOLUTION FOR INJECTION 5 mg/mL