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Mannitol
go.drugbank.com/drugs/DB00742ApprovedInvestigationalAs a result, cerebral edema, elevated intracranial pressure, and cerebrospinal fluid volume and pressure may be reduced. … Mannitol may also be used for the promotion of diuresis before irreversible renal failure becomes established; the promotion of urinary excretion of toxic substances; as an Antiglaucoma agent; and as a
Synonyms: D-Mannitol, D-(-)-MannitolInternational brands: Mannisol APromazine
go.drugbank.com/drugs/DB00420ApprovedVet approvedWithdrawnA phenothiazine with actions similar to chlorpromazine but with less antipsychotic activity. It is primarily used in short-term treatment of disturbed behavior and as an antiemetic.
Synonyms: N,N-dimethyl-3-(10H-phenothiazin-10-yl)-propan-1-amine, N-(3-Dimethylaminopropyl)phenothiazineCategories: Cytochrome P-450 Substrates, Adrenergic alpha-1 Receptor AntagonistsDebrisoquine
go.drugbank.com/drugs/DB04840ApprovedAn adrenergic neuron-blocking drug similar in effects to guanethidine. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. … Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs.
Categories: P-glycoprotein substrates, Cytochrome P-450 SubstratesLicorice
go.drugbank.com/drugs/DB10675ApprovedLicorice allergenic extract is used in allergenic testing.
Mixtures: HAN SHIN GAMKONAL Extract Granules, HAN SHIN GAMKONAL Extract GranulesPegcetacoplan
go.drugbank.com/drugs/DB16694ApprovedInvestigational[A235000,A235005] Pegcetacoplan was developed out of a need for an inhibitor of complement mediated hemolysis further upstream of C5. … [A235000,A235005] Pegcetacoplan is a pegylated C3 inhibitor that can disrupt the processes leading to both forms of hemolysis that threaten patients with PNH.
Products: EMPAVELI® 54 MG/ML SOLUCIÓN INYECTABLETioguanine
go.drugbank.com/drugs/DB00352ApprovedInvestigationalAn antineoplastic compound which also has antimetabolite action. The drug is used in the therapy of acute leukemia.
Categories: Heterocyclic Compounds, 2-RingSynonyms: 2-Aminopurin-6-thiol, 2-Amino-6-purinethiolChenodeoxycholic acid
go.drugbank.com/drugs/DB06777ApprovedInvestigationalChenodeoxycholic acid (or Chenodiol) is an epimer of ursodeoxycholic acid (DB01586). Chenodeoxycholic acid is a bile acid naturally found in the body. … It can also reduce the amount of other bile acids that can be harmful to liver cells when levels are elevated.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP3A SubstratesBendazac
go.drugbank.com/drugs/DB13501ApprovedWithdrawnBendazac is an oxyacetic acid [A39863, A39869]. … small handful of regions may continue to have the medication available for purchase and use either as a topical anti-inflammatory/analgesic cream or eye drop formulation.
Categories: Non COX-2 selective NSAIDS, Heterocyclic Compounds, 1-RingPeanut oil
go.drugbank.com/drugs/DB13964ApprovedWithdrawnPeanut oil is derived from _Arachis hypogaea_ which can be found in South America, Mexico, and Centro America. … [A33169] Under the FDA, peanut oil is categorized as an approved inactive ingredient for its use in drug products.
Products: Oilatum Soap - 2%Pixantrone
go.drugbank.com/drugs/DB06193ApprovedWithdrawnPixantrone is an aza-anthracenedione and DNA intercalator which inhibits topoisomerase II. … It is similar in structure to anthracyclines such as mitoxantrone, but exerts fewer toxic effects on cardiac tissue. [2] The lower cardio-toxic effects of pixantrone may be explained, in part, by its redox
Synonyms: 6,9-bis((2-aminoethyl)amino)benzo(g)isoquinoline-5,10-dioneCategories: Heterocyclic Compounds, 2-Ring