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Displaying results 9291 - 9300 of 10000 in total
  1. Drug

    Ivarmacitinib

    go.drugbank.com/drugs/DB16756
    Investigational

    Ivarmacitinib (SHR0302) is a selective inhibitor of Janus kinase 1 (JAK1) under investigation for the treatment of various immuno-inflammatory conditions.

    Categories: Janus Kinase 1, antagonists & inhibitors
  2. Drug

    Tebipenem pivoxil

    go.drugbank.com/drugs/DB16840
    Approved

    Tebipenem pivoxil is an orally administered prodrug of tebipenem, a carbapenem antibacterial that kills bacteria by binding essential penicillin-binding proteins and disrupting cell wall biosynthesis. … severe or resistant Gram-negative infections but had until now been available only intravenously, meaning patients with resistant complicated urinary tract infections generally required hospitalization, a

    Categories: MATE 1 Substrates, MATE 2 Substrates
  3. Drug

    Tosufloxacin

    go.drugbank.com/drugs/DB16850
    Experimental

    Categories: 4-Quinolones, Heterocyclic Compounds, 2-Ring
  4. Drug

    L-Acetylleucine

    go.drugbank.com/drugs/DB16956
    ApprovedInvestigational

    [A264439] Observational studies in patients with Niemann-Pick disease type C (NPC) suggested a beneficial symptomatic as well as neuroprotective disease-modifying effect of the DL-form of N-acetylleucine … Levacetylleucine (L-acetylleucine) is a modified acetylated derivative of the amino acid [leucine]. The racemic (i.e. DL-) form has been available in France since 1957 for the treatment of vertigo.

    Categories: P-glycoprotein inhibitorsSynonyms: (s)-2-acetamido-4-methylpentanoic acid, L-leucine, n-acetyl-
  5. Drug

    NP-51

    go.drugbank.com/drugs/DB16995
    Investigational

    Synonyms: 3-pyridinecarboximidamide, n-(2-hydroxy-3-(1-piperidinyl)propoxy)-, (+/-)-o-(3-piperidino-2-hydroxy-1-propyl)nicotinic acid amidoximeCategories: Heterocyclic Compounds, 1-Ring
  6. Drug

    Nutlin-3

    go.drugbank.com/drugs/DB17039
    Experimental

    Nutlin-3 is a small molecule inhibitor that targets p53-Mdm2 interaction.[A253057]

    Categories: Heterocyclic Compounds, 1-RingSynonyms: 2-piperazinone, 4-(((4r,5s)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-(4-methoxy-2-(1-methylethoxy)phenyl)-1h-imidazol-1-yl)carbonyl)-, rel-, Nutlin-3
  7. Drug

    PHA-767491

    go.drugbank.com/drugs/DB17043
    Investigational

    PHA-767491 is a Cdc7/CDK9 inhibitor.[A253077]

    Categories: Heterocyclic Compounds, 1-Ring
  8. Drug

    Vorasidenib

    go.drugbank.com/drugs/DB17097
    ApprovedInvestigational

    Vorasidenib is a first-in-class dual isocitrate dehydrogenase-1 (IDH1) and isocitrate dehydrogenase-2 (IDH2) inhibitor. … [A264209] It works by suppressing the levels of D-2-hydroxyglutarate (2-HG), an oncometabolite produced by mutant IDH1 and IDH2 isoforms.

    Categories: Cytochrome P-450 CYP2B6 Inducers, Cytochrome P-450 SubstratesSynonyms: 1,3,5-triazine-2,4-diamine, 6-(6-chloro-2-pyridinyl)-n2,n4-bis((1r)-2,2,2-trifluoro-1-methylethyl)-
  9. Drug

    Seclidemstat

    go.drugbank.com/drugs/DB17117
    Investigational

    Synonyms: Benzoic acid, 3-((4-methyl-1-piperazinyl)sulfonyl)-, (2e)-2-(1-(5-chloro-2-hydroxyphenyl)ethylidene)hydrazide, N'-[(1E)-1-(5-chloro-2-hydroxyphenyl)ethylidene]- 3-(4-methylpiperazine-1-sulfonyl)benzohydrazideCategories: Heterocyclic Compounds, 1-Ring
  10. Drug

    IM-156 free base

    go.drugbank.com/drugs/DB17121
    Investigational

    Synonyms: 1-pyrrolidinecarboximidamide, n-(imino((4-(trifluoromethoxy)phenyl)amino)methyl)-, 1-Pyrrolidinecarboximidamide, N-[imino[[4-(trifluoromethoxy)phenyl]amino]methyl]-Categories: Heterocyclic Compounds, 1-Ring