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Polyethylene glycol
go.drugbank.com/drugs/DB09287ApprovedInvestigationalVet approvedPEGs have a long history of gastroenterology: PEG 3350 is a common over-the-counter osmotic laxative used to relieve occasional constipation. … [A190975,A190978] PEGs are water-soluble polymers that can form hydrogen bonds in a ratio of 100 water molecules per one PEG molecule.
Mixtures: Gavilyte-N, DAXTELY FCategories: P-glycoprotein inhibitors, Compounds used in a research, industrial, or household settingOmbitasvir
go.drugbank.com/drugs/DB09296ApprovedInvestigationalOmbitasvir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). … HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in the United States, and affecting 72% of all chronic HCV patients [L852].
Categories: P-glycoprotein substrates, Treatments for Hepatitis CSynonyms: dimethyl ([(2S,5S)-1-(4-tert-butylphenyl)pyrrolidine-2,5-diyl]bis{(4,1-phenylene)carbamoyl(2S)pyrrolidine-2,1-diyl[(2S)-3-methyl-1-oxobutane-1,2-diyl]})biscarbamateParitaprevir
go.drugbank.com/drugs/DB09297ApprovedInvestigationalParitaprevir is a direct acting antiviral medication used as part of combination therapy to treat chronic Hepatitis C, an infectious liver disease caused by infection with Hepatitis C Virus (HCV). … HCV is a single-stranded RNA virus that is categorized into nine distinct genotypes, with genotype 1 being the most common in the United States, and affecting 72% of all chronic HCV patients [L852].
Categories: Cytochrome P-450 Substrates, P-glycoprotein substratesSynonyms: (2R,6S,12Z,13aR,14aR,16aS)-N-(cyclopropanesulfonyl)-6-[(5-methylpyrazine-2-carbonyl)amino]-5,16-dioxo-2-[(phenanthridin-6-yl)oxy]-1,2,3,6,7,8,9,10,11,13a,14,15,16,16a-tetradecahydrocyclopropa[e]pyrrolo, [1,2-a][1,4]diazacyclopentadecine-14a(5H)-carboxamideAlirocumab
go.drugbank.com/drugs/DB09302ApprovedInvestigationalAlirocumab is a biopharmaceutical that obtained FDA approval in July 2015 as a second line treatment for high cholesterol in adults whose LDL-cholesterol (LDL-C) is not controlled by the combination of … PCSK9 inhibition facilitates more LDL-C clearance from the blood.
Categories: Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) InhibitorsProducts: PRALUENT®150MG/ML SOLUCIÓN INYECTABLE, PRALUENT® 75MG/ML SOLUCIÓN INYECTABLEAptazapine
go.drugbank.com/drugs/DB09305ExperimentalAptazapine (CGS-7525A) was a tetracyclic antidepressant developed in the 1980s. Aptazapine had noradrenergic and specific serotonergic activity. … It antagonised α2 adrenergic receptors approximately 10 times more effectively than mianserin, antagonised 5-HT2 receptors, agonised H1 receptors, and did not affect reuptake of serotonin or norepinephrine
Categories: Heterocyclic Compounds, 2-RingSolithromycin
go.drugbank.com/drugs/DB09308InvestigationalSolithromycin is a ketolide antibiotic undergoing clinical development for the treatment of community-acquired pneumonia (CAP) and other infections.
Categories: P-glycoprotein inhibitors, P-glycoprotein substratesAntilymphocyte immunoglobulin (horse)
go.drugbank.com/drugs/DB09312ApprovedInvestigationalInduction of T cell apoptosis and resulting T-cell lymphopenia found in vivo is credited for its therapeutic effect in these conditions. … It is formed by inoculating a horse with an antigen (human thymoyctes) which then induces the horse immune system's B-lymphocytes to produce IgG immunoglobulins specific for that antigen.
Categories: Immunoglobulin G, Increased T Lymphocyte DestructionSynonyms: e-ATG, h-ATGTegafur-uracil
go.drugbank.com/drugs/DB09327ApprovedTegafur-uracil is an anti-tumor compound containing tegafur (1-(2-tetrahydrofuryl)-5-fluorouracil) and uracil in a molar ratio of 1:4.
Categories: Cytochrome P-450 Substrates, Cytochrome P-450 CYP2A6 SubstratesInvert sugar
go.drugbank.com/drugs/DB09344Experimental[A32124] Invert sugar is FDA approved since 1988 as a safe substance (GRAS).
Categories: Compounds used in a research, industrial, or household settingGastric intrinsic factor
go.drugbank.com/drugs/DB09349ApprovedIntrinsic factor (IF), also known as gastric intrinsic factor (GIF), is a glycoprotein produced by the parietal cells of the stomach that is necessary for the absorption of vitamin B12 (cobalamin) later