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Displaying results 941 - 950 of 10000 in total
  1. Drug

    RS-39604

    go.drugbank.com/drugs/DB17050
    Experimental

    RS-39604 is a selective 5-HT4 receptor antagonist.[A253112]

    Synonyms: Methanesulfonamide, n-(2-(4-(3-(4-amino-5-chloro-2-((3,5-dimethoxyphenyl)methoxy)phenyl)-3-oxopropyl)-1-piperidinyl)ethyl)-Salts: RS-39604 hydrochloride
  2. Drug

    Turoctocog alfa pegol

    go.drugbank.com/drugs/DB14738
    ApprovedInvestigational

    Fundamentally, the N8-GP moiety is identical to [turoctocog alfa], a recombinant human clotting factor VIII (rFVIII) with a truncated B-domain made from the sequence coding for 10 amino acids from the … During secretion, some rFVIII molecules are cleaved at the C-terminal of the heavy chain (HC) at amino acid 720, and a monoclonal antibody binding C-terminal to this position is used in the purification

    Products: ESPEROCT® 1500 UI, ESPEROCT® 2000 UI
  3. Drug

    Articaine

    go.drugbank.com/drugs/DB09009
    ApprovedInvestigational

    Articaine is a dental local anesthetic. Articaine is widely used around the world and is the most popular local anesthetic in many European countries.

    Mixtures: ARTHEEK(R) ARTICAINA AL 4% CON EPINEFRINA 1:100.000, ARTHEEK SP®Categories: Heterocyclic Compounds, 1-Ring
  4. Drug

    Idebenone

    go.drugbank.com/drugs/DB09081
    ApprovedInvestigational

    Idebenone is a synthetic analogue of ubiquinone (also known as Coenzyme Q10), a vital cell antioxidant and essential component of the Electron Transport Chain (ETC). … LHON is a mitochondrially inherited degeneration of retinal ganglion cells, resulting in acute central vision loss.

    Mixtures: EVERON 90/5 MG FILM KAPLI TABLET ,50 TABLET, EVERON 90/5 MG FILM KAPLI TABLET ,100 TABLETCategories: Compounds used in a research, industrial, or household setting
  5. Drug

    Ivacaftor

    go.drugbank.com/drugs/DB08820
    ApprovedInvestigational

    Ivacaftor (also known as Kalydeco or VX-770) is a drug used for the management of Cystic Fibrosis (CF). It is manufactured and distributed by Vertex Pharmaceuticals. … [L6841] Ivacaftor is administered as a monotherapy and also administered in combination with other drugs for the management of CF.

    Synonyms: N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamideCategories: P-glycoprotein inhibitors, Cytochrome P-450 Substrates
  6. Drug

    Pramocaine

    go.drugbank.com/drugs/DB09345
    Approved

    Pramocaine (also known as pramoxine or pramoxine HCI) is a topical anesthetic and antipruritic. … Pramocaine is available by itself and in combination with other medications in various topical preparations.

    Mixtures: Oti Rx, Itch-XCategories: Heterocyclic Compounds, 1-Ring
  7. Drug

    Valrubicin

    go.drugbank.com/drugs/DB00385
    Approved

    Valrubicin (N-trifluoroacetyladriamycin-14-valerate) is a chemotherapy drug commonly marketed under the trade name VALSTAR. … It is a semisynthetic analog of the [doxorubicin], which is an anthracycline drug. Used in the treatment of the bladder cancer, valrubicin is administered by direct infusion into the bladder.

    Categories: Topoisomerase II InhibitorsSynonyms: (8S, 10S)-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-10-[[2,3,6-trideoxy-3-(2,2,2-trifluoroacetamido)-α-L-lyxo-hexopyranosyl]oxy]-5,12-naphthacenedione 8²-valerate, 2-oxo-2-[(2S,4S)-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-4-({2,3,6-trideoxy-3-[(trifluoroacetyl)amino]hexopyranosyl}oxy)-1,2,3,4,6,11-hexahydrotetracen-2-yl]ethyl pentanoate
  8. Drug

    Zinc phenolsulfonate

    go.drugbank.com/drugs/DB15793
    ApprovedWithdrawn

    Synonyms: Zinc p-phenolsulfonate, Zinc p-phenolsulphonateMixtures: Sil Trax Plus No 8, Sil Trax Plus No 9
  9. Drug

    Bamocaftor

    go.drugbank.com/drugs/DB15177
    Investigational

    Bamocaftor (VX-659) is under investigation in clinical trial NCT03224351 (A Study Evaluating the Safety and Efficacy of VX-659 Combination Therapy in Subjects With Cystic Fibrosis).

    Categories: Heterocyclic Compounds, 1-RingSynonyms: 3-Pyridinecarboxamide, N-(phenylsulfonyl)-6-(3-(2-(1-(trifluoromethyl)cyclopropyl)ethoxy)-1H-pyrazol-1-yl)-2-((4S)-2,2,4-trimethyl-1-pyrrolidinyl)-, N-(benzenesulfonyl)-6-[3-[2-[1-(trifluoromethyl)cyclopropyl]ethoxy]pyrazol-1-yl]-2-[(4S)-2,2,4-trimethylpyrrolidin-1-yl]pyridine-3-carboxamide
  10. Drug

    Moroctocog alfa

    go.drugbank.com/drugs/DB13999
    Approved

    a co-factor to Factor IX. … Activation of Factor IX leads to a cascade of signals that results in activation of Factor X, which then results in the conversion of prothrombin to thrombin, and as a result, leads to the conversion of

    Synonyms: B-domain deleted recombinant factor VIII, Human factor VIII, recombinant B-domain deletedProducts: XYNTHA® 2000 UI, XYNTHA® 250 UI POLVO LIOFILIZADO PARA SOLUCION INYECTABLE