Articaine

DB09009ApprovedInvestigationalSmall moleculeLocal Anesthetics (Amide)

Articaine is a local anesthetic used for inducing local, infiltrative, or conductive anesthesia in both simple and complex dental procedures. Articaine is widely used around the world and is the most popular local anesthetic in many European countries.

Chemical structure of Articaine
Mechanism
Curator reviewed
Formula / weight
C13H20N2O3S · 284.374 g/mol (avg)
First approval
Canada, 2000 · United States, 2000
Code names
HOE 045
Brand names
  • Articadent
  • Astracaine
  • Cyklx
  • Orabloc
  • Septanest
  • Septocaine
  • Ultacan
  • Ultracaine
  • Zorcaine

Resolves to

Compound
UNIID3SQ406G9XCAS23964-58-1ChEMBLCHEMBL1093ChEBI91834PubChem32170KEGGD07468
Clinical / RWD
RxNorm592464ATCN01BB08ATCN01BB58
Structure
InChIKeyQTGIAADRBBLJGA-UHFFFAOYSA-NSMILESCCCNC(C)C(=O)NC1=C(SC=C1C)C(=O)OC

What you can answer from here — as of September 23, 2026

1Protein targetEach mapped to UniProt, with action and pharmacological action
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1,728Drug interactionsStructured to mechanism, not free text
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75Clinical trialsPhase, status and sponsor resolved per trial
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2Structured indicationsCondition, population, route and combination as fields, not prose
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1ContraindicationEach with its own population and attribute set
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134Marketed productsAcross 10 countries and 44 labellers
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2ATC codesIncluding every combination product, plus 14 drug categories
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6+ReferencesStructured and connected to the statements they support
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Which other approved drugs treat the same conditions as Articaine, and which companies have late-stage candidates in those indications?

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