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Caramiphen
go.drugbank.com/drugs/DB11504ExperimentalVet approvedAdditionally, it is used, in combination with [phenylpropanolamine], as a cough suppressant and nasal decongestant for the symptomatic treatment of seasonal respiratory conditions. … Caramiphen is a cholinergic antagonist used in Parkinson's disease.
Flurazepam
go.drugbank.com/drugs/DB00690ApprovedIllicitA benzodiazepine derivative used mainly as a hypnotic.
Categories: P-glycoprotein inhibitors, Cytochrome P-450 SubstratesTrastuzumab botidotin
go.drugbank.com/drugs/DB17413ExperimentalA166 is an antibody-drug conjugate composed of a novel cytotoxic drug (Duo-5, anti-microtubule agent) site-specifically conjugated to an anti-HER2 antibody (trastuzumab) via a stable protease-cleavable
Synonyms: Recombinant humanized IgG1 anti-HER2 monoclonal antibody conjugated to Duostatin-5Zodasiran
go.drugbank.com/drugs/DB17626InvestigationalIt was granted an orphan drug designation for the treatment of homozygous familial hypercholesterolemia (HoFH).[L45869] … ARO-ANG3 is a subcutaneously administered RNA interference (RNAi)-based investigational medicine targeting angiopoietin-like protein 3 (ANGPTL3).
AZD-8186
go.drugbank.com/drugs/DB15029InvestigationalBe Removed by Surgery). … AZD-8186 is under investigation in clinical trial NCT03218826 (PI3Kbeta Inhibitor AZD8186 and Docetaxel in Treating Patients Advanced Solid Tumors With PTEN or PIK3CB Mutations That Are Metastatic or Cannot
Categories: Heterocyclic Compounds, 1-Ring, Heterocyclic Compounds, 2-RingIopofosine I-131
go.drugbank.com/drugs/DB15244InvestigationalIopofosine I-131 (NM-404 I-131) is under investigation in clinical trial NCT01495663 (Dose Escalation Study of I-131-CLR1404 in Subjects With Cancer That Does Not Respond to Treatment or Has Returned).
Synonyms: Ethanaminium, 2-((hydroxy((18-(4-(iodo-131I)phenyl)octadecyl)oxy)phosphinyl)oxy)-N,N,N-trimethyl-, inner salt, 2-((HYDROXY((18-(4-(131I)IODOPHENYL)OCTADECYL)OXY)PHOSPHINYL)OXY)-N,N,NTRIMETHYLETHANAMINIUM INNER SALTNitarsone
go.drugbank.com/drugs/DB11437ExperimentalVet approvedNitarsone is an organoarsenic compound. It is used as an additive in poultry feed to improve weight gain and feed efficiency, while preventing blackhead disease. … It is marketed as Histostat by Zoetis, a publicly traded subsidiary of Pfizer.
Synonyms: (p-nitrophenyl)arsonic acid, 4-nitrobenzenearsonic acidPemlimogene merolisbac
go.drugbank.com/drugs/DB16286InvestigationalVersus Nivolumab Monotherapy in Participants With Advanced Adenocarcinoma of the Lung). … Pemlimogene merolisbac is under investigation in clinical trial NCT03371381 (An Efficacy and Safety Study of JNJ-64041757, a Live Attenuated Listeria Monocytogenes Immunotherapy, in Combination With Nivolumab
Synonyms: Recombinant live-attenuated double-deleted (ladd) strain of listeria monocytogenes (lm .delta.acta/.delta.inlb) expressing a fusion protein comprising the n-terminal 100 amino acids of the lm acta protein, (actan100), 5 tandem copies of a 21 amino acid frSNS01-T
go.drugbank.com/drugs/DB17302InvestigationalSNS01-T is a gene therapy nanoparticle. … It is composed of three components: a B cell-specific plasmid expressing eIF5AK50R; an siRNA that targets the native eIF5A that promotes growth/anti-apoptosis of cancer cells; and polyethylenimine.
PLX51107
go.drugbank.com/drugs/DB17543InvestigationalPLX51107 is a potent and selective inhibitor of the bromodomain and extraterminal (BET) protein family. … [A257246,A257251] PLX51107 is under investigation in clinical trial NCT04022785 (PLX51107 and Azacitidine in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome).
Categories: Heterocyclic Compounds, 1-RingSynonyms: Benzoic acid, 4-(6-(3,5-dimethyl-4-isoxazolyl)-1-((1s)-1-(2-pyridinyl)ethyl)-1h-pyrrolo(3,2-b)pyridin-3-yl)-