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mRNA-1283
go.drugbank.com/drugs/DB22668ApprovedInvestigational[L53408] As opposed to previously approved COVID-19 mRNA vaccines, including the original [Moderna COVID-19 Vaccine], mRNA-1283 encodes only the immunodominant regions (NTD and RBD) of the SARS-CoV- … [L53413,A274083] mNEXSPIKE was approved by the US FDA in June 2025 for use in patients who have been previously vaccinated with any COVID-19 vaccine and who are at a higher risk of severe outcomes from
Nicergoline
go.drugbank.com/drugs/DB00699ApprovedAn ergot derivative that has been used as a cerebral vasodilator and in peripheral vascular disease. It has been suggested to ameliorate cognitive deficits in cerebrovascular disease.
Xylitol
go.drugbank.com/drugs/DB11195ApprovedInvestigationalIt is widely used as a sugar substitute and in "sugar-free" food products.
Pepsin
go.drugbank.com/drugs/DB13198ApprovedWithdrawnMany causes of pancreatic insufficiency require that enzyme replacement therapy is started, including cystic fibrosis, pancreatic cancer, acute and chronic pancreatitis, as well as pancreatic surgery [ … Pepsin is often used as a replacement enzyme for those with pancreatic insufficiency [L2357].
Aspartame
go.drugbank.com/drugs/DB00168InvestigationalNutraceuticalFlavoring agent sweeter than sugar, metabolized as phenylalanine and aspartic acid.
Verteporfin
go.drugbank.com/drugs/DB00460ApprovedInvestigationalIt is used as a photosensitizer in photodynamic therapy to eliminate abnormal blood vessels in wet form macular degeneration. … Verteporfin, marketed as Visudyne, is a benzoporphyrin derivative comprising a 50:50 mixture of two isomers: [CL-315555] and [CL-315585].
Indigotindisulfonic acid
go.drugbank.com/drugs/DB11577ApprovedInvestigational[A32490,A32491,A32492,L2222] Its salt form, indigotindisulfonate sodium, is also known as indigo carmine, indigotine or FD&C Blue #2. … [A251405] Indigotindisulfonic acid is used in clinical medicine to determine patency of the urinary collecting system, and to assist in specific surgical procedures such as cystourethroscopy.
Calcium glubionate anhydrous
go.drugbank.com/drugs/DB13142ApprovedCalcium glubionate (or glubionate calcium) is a mineral supplement to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets.
Setmelanotide
go.drugbank.com/drugs/DB11700ApprovedInvestigational[A224449] Earlier attempts at agonizing MC4R (such as LY2112688) lead to successful weight loss, but also an increase in blood pressure and heart rate.
Tranexamic acid
go.drugbank.com/drugs/DB00302ApprovedInvestigationalTranexamic acid is a synthetic derivative of [lysine] used as an antifibrinolytic in the treatment and prevention of major bleeding. … [L31883] It was first patented in 1957[A230108] and received its initial US approval in 1986.[L31858]