Aspartame

DB00168InvestigationalNutraceuticalSmall molecule

Flavoring agent sweeter than sugar, metabolized as phenylalanine and aspartic acid.

Chemical structure of Aspartame
Mechanism
Curator reviewed
Primary indication
Used as a diet supplement and sugar substitute.Curator reviewed · 1 structured indication
Formula / weight
C14H18N2O5 · 294.3031 g/mol (avg)
Also known as
Asp-phe-ome · Aspartylphenylalanine methyl ester
Code names
E-951 · SC-18862

Resolves to

Compound
UNIIZ0H242BBR1CAS22839-47-0ChEMBLCHEMBL171679ChEBI2877PubChem6992066KEGGD02381
Clinical / RWD
RxNorm1311524PharmGKBPA448493
Structure
InChIKeyIAOZJIPTCAWIRG-QWRGUYRKSA-NSMILESCOC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@@H](N)CC(O)=O
Targets
Q7RTX0TAS1R3Q8TE23TAS1R2Q8NER1TRPV1
Transporters
Q4U2R8SLC22A6Q8TCC7SLC22A8Q9NSA0SLC22A11

What you can answer from here — as of September 23, 2026

3Protein targetsEach mapped to UniProt, with action and pharmacological action
Listed above
3TransportersSubstrate / inhibitor direction, not just membership
Listed above
79Drug interactionsStructured to mechanism, not free text
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3Clinical trialsPhase, status and sponsor resolved per trial
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1Structured indicationCondition, population, route and combination as fields, not prose
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27Marketed productsAcross 3 countries and 11 labellers
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8+ReferencesStructured and connected to the statements they support
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