Indigotindisulfonic acid is a medication used to visualize ureteral orifices during cystoscopy and ureteral catheterization. Indigotindisulfonic acid is a blue-colored dye with a variety of uses.
- Mechanism
- Curator reviewed · 4 references
Indigotindisulfonic acid is a biologically inert blue dye. After intravenous injection, indigotindisulfonic acid is excreted by the kidney through tubular secretion and, with its deep blue color, it enhances visualization of the ureteral orifices. Because of this, indigotindisulfonic acid is used to identify ureteral patency in urologic and gynecologic procedures.
Indigotindisulfonic acid may lead to the development of hypertension. It has been suggested that indigotindisulfonic acid inhibits endothelium-dependent relaxation at the level of nitric oxide generation and/or its release from the endothelium. Also, indigotindisulfonic acid appears to inhibit vascular guanylyl cyclase in smooth muscle.
- Primary indication
- The main application of indigotindisulfonic acid is localizing and visualizing ureteral orifices during cystoscopy and ureteral catheterization procedures.Curator reviewed · 2 structured indications
- Formula / weight
- C16H10N2O8S2 · 422.389 g/mol (avg)
- First approval
- Canada, 2010 · United States, 2022
- Also known as
- Blue X · FD&C Blue #2 · Indigo carmine · Indigo carmine acid · indigo carmine free acid
- Code names
- NSC-8646
- Brand names
Resolves to
CFZXDJWFRVEWSR-BUHFOSPRSA-NSMILESOS(=O)(=O)C1=CC2=C(N\C(C2=O)=C2\NC3=C(C=C(C=C3)S(O)(=O)=O)C2=O)C=C1What you can answer from here — as of September 14, 2026
Which other approved drugs treat the same conditions as Indigotindisulfonic acid, and which companies have late-stage candidates in those indications?
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